ENSG00000113558


Homo sapiens

Features
Gene ID: ENSG00000113558
  
Biological name :SKP1
  
Synonyms : P63208 / SKP1 / S-phase kinase associated protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.1
Gene start: 134148935
Gene end: 134177038
  
Corresponding Affymetrix probe sets: 200711_s_at (Human Genome U133 Plus 2.0 Array)   200718_s_at (Human Genome U133 Plus 2.0 Array)   200719_at (Human Genome U133 Plus 2.0 Array)   207974_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429415
Ensembl peptide - ENSP00000429472
Ensembl peptide - ENSP00000431067
Ensembl peptide - ENSP00000430885
Ensembl peptide - ENSP00000429996
Ensembl peptide - ENSP00000429995
Ensembl peptide - ENSP00000429961
Ensembl peptide - ENSP00000429686
Ensembl peptide - ENSP00000231487
Ensembl peptide - ENSP00000331708
Ensembl peptide - ENSP00000428962
NCBI entrez gene - 6500     See in Manteia.
OMIM - 601434
RefSeq - NM_170679
RefSeq - NM_006930
RefSeq Peptide - NP_008861
RefSeq Peptide - NP_733779
swissprot - E5RGM4
swissprot - E5RGM3
swissprot - F8W8N3
swissprot - E7ERH2
swissprot - P63208
swissprot - E5RK33
swissprot - E5RJR5
swissprot - E5RHM3
Ensembl - ENSG00000113558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skp1ENSDARG00000003151Danio rerio
 SKP1ENSGALG00000006474Gallus gallus
 Skp1aENSMUSG00000036309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC104109.3ENSG0000027277234


Protein motifs (from Interpro)
Interpro ID Name
 IPR001232  S-phase kinase-associated protein 1-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR016072  SKP1 component, dimerisation
 IPR016073  SKP1 component, POZ domain
 IPR016897  S-phase kinase-associated protein 1
 IPR036296  SKP1-like, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006879 cellular iron ion homeostasis TAS
 biological_processGO:0010265 SCF complex assembly TAS
 biological_processGO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0035518 histone H2A monoubiquitination IDA
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051457 maintenance of protein location in nucleus IPI
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031519 PcG protein complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA
 molecular_functionGO:0097602 cullin family protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / complex / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / complex / reaction
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / complex / reaction
 ENSG00000105173 CCNE1 / P24864 / cyclin E1  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / complex / reaction
 ENSG00000103479 RBL2 / Q08999 / RB transcriptional corepressor like 2  / complex / reaction
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / complex / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / complex / reaction
 ENSG00000087586 AURKA / O14965 / aurora kinase A  / complex / reaction
 ENSG00000175305 CCNE2 / O96020 / cyclin E2  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000183580 FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7  / complex / reaction
 ENSG00000118564 FBXL5 / Q9UKA1 / F-box and leucine rich repeat protein 5  / complex / reaction
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / complex / reaction
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / complex / reaction
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / complex / reaction
 ENSG00000109670 FBXW7 / Q969H0 / F-box and WD repeat domain containing 7  / complex
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000173207 CKS1B / P61024 / CDC28 protein kinase regulatory subunit 1B  / complex / reaction
 ENSG00000148400 NOTCH1 / P46531  / complex / reaction
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / complex / reaction
 ENSG00000145604 SKP2 / Q13309 / S-phase kinase associated protein 2  / complex
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex / reaction
 ENSG00000172179 PRL / P01236 / prolactin  / complex / reaction
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / complex / reaction
 ENSG00000188215 Q8IWE4 / DCUN1D3 / defective in cullin neddylation 1 domain containing 3  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / complex / reaction
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000155034 FBXL18 / Q96ME1 / F-box and leucine rich repeat protein 18  / complex
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / complex / reaction






 

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