ENSGALG00000006474


Gallus gallus

Features
Gene ID: ENSGALG00000006474
  
Biological name :SKP1
  
Synonyms : Q5ZKF5 / SKP1 / S-phase kinase-associated protein 1
  
Possible biological names infered from orthology : AC104109.3 / P63208 / Q9WTX5 / Skp1a / S-phase kinase-associated protein 1A
  
Species: Gallus gallus
  
Chr. number: 13
Strand: 1
Band:
Gene start: 15996718
Gene end: 16005007
  
Corresponding Affymetrix probe sets: Gga.1718.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000010447
Ensembl peptide - ENSGALP00000048383
NCBI entrez gene - 416319     See in Manteia.
RefSeq - NM_001006153
RefSeq Peptide - NP_001006153
swissprot - Q5ZKF5
Ensembl - ENSGALG00000006474
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skp1ENSDARG00000003151Danio rerio
 AC104109.3ENSG00000272772Homo sapiens
 SKP1ENSG00000113558Homo sapiens
 Skp1aENSMUSG00000036309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001232  S-phase kinase-associated protein 1-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR016072  SKP1 component, dimerisation
 IPR016073  SKP1 component, POZ domain
 IPR016897  S-phase kinase-associated protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISS
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex ISS


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002085 FZR1 / fizzy-related protein homolog / Q9R1K5* / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSGALG00000002229 FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *  / complex
 ENSGALG00000004611 FBXL18 / F-box and leucine rich repeat protein 18 / Q96ME1*  / complex
 ENSGALG00000008931 COMMD1 / copper metabolism domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 *  / complex
 ENSGALG00000000249 GH / P08998 / Somatotropin / GH2* / GH1* / CSH1* / CSH2* / CSHL1* / Q14406* / P0DML3* / P0DML2* / P01241* / P01242* / P06880* / growth hormone 1* / growth hormone 2* / chorionic somatomamm...  / complex / reaction
 ENSGALG00000002267 DCUN1D3 / defective in cullin neddylation 1 domain containing 3 / Q8IWE4* / Q8K0V2* / DCN1-like protein 3 *  / complex / reaction
 ENSGALG00000007356 MAP3K8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / complex / reaction
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / complex / reaction
 ENSGALG00000044525 NFKBIE / NFKB inhibitor epsilon / O00221* / O54910* / NF-kappa-B inhibitor epsilon *  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000012671 prl / P14676 / Prolactin / P04095* / P04768* / P04769* / P06879* / P09586* / Prl2a1* / Prl2b1* / Prl2c1* / Prl2c2* / Prl2c3* / Prl2c5* / Prl3a1* / Prl3b1* / Prl3c1* / Prl3d1* / Prl3d2* / P...  / complex / reaction
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / complex / reaction
 ENSGALG00000007768 AURKA / aurora kinase A / O14965* / P97477*  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000022980 CDKN1B / cyclin dependent kinase inhibitor 1B / P46414* / P46527*  / complex / reaction
 ENSGALG00000007845 REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*  / complex / reaction
 ENSGALG00000040794 CCNE2 / cyclin E2 / O96020* / Q9Z238* / G1/S-specific cyclin-E2 *  / complex / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000029691 NFKBIB / NFKB inhibitor beta / Q15653* / Q60778* / NF-kappa-B inhibitor beta *  / complex / reaction
 ENSGALG00000009971 CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *  / complex / reaction
 ENSGALG00000028664 CKS1B / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / complex / reaction
 ENSGALG00000040276 RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr