ENSGALG00000007845


Gallus gallus
transcriptionregulationRELdomainrnapolymeraseiidna-bindingrelhomologynf-kappabdnabindingfactordna-templatedi-kappabkinasesignalingdistalenhancersequence-specificactivitynf-kappa-bdorsaliptp-likerhdimmunoglobulin-likefoldimmunoglobulin

Features
Gene ID: ENSGALG00000007845
  
Biological name :REL
  
Synonyms : REL / REL proto-oncogene, NF-kB subunit
  
Possible biological names infered from orthology : Q04864 / reticuloendotheliosis oncogene
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 2035832
Gene end: 2069776
  
Corresponding Affymetrix probe sets: Gga.10724.1.S1_at (Chicken Array)   Gga.4396.1.S1_at (Chicken Array)   X02759.CDS1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053509
Ensembl peptide - ENSGALP00000039504
NCBI entrez gene - 396500     See in Manteia.
RefSeq - XM_015283289
RefSeq - NM_001167726
RefSeq - XM_015283288
RefSeq Peptide - NP_001161198
swissprot - F1P3A5
swissprot - A0A1D5PKZ5
Ensembl - ENSGALG00000007845
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 relENSDARG00000055276Danio rerio
 RELENSG00000162924Homo sapiens
 RelENSMUSG00000020275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*ENSGALG0000001230429
NFKB2 / nuclear factor NF-kappa-B p100 subunit / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2* / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100*ENSGALG0000000565326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030505  Proto-oncogene c-Rel
 IPR032397  Rel homology dimerisation domain


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscytokine productionnitrogen compoundnitrogen compound metabolic processbiosynthetic procbiosynthetic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processcell communicatiocell communicationcellular responsecellular response to stimuluscytokine producticytokine production
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityDNA-binding transcription factor activity
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0032688 negative regulation of interferon-beta production IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002229 FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *  / complex / reaction
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000044525 NFKBIE / NFKB inhibitor epsilon / O00221* / O54910* / NF-kappa-B inhibitor epsilon *  / complex
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex
 ENSGALG00000029691 NFKBIB / NFKB inhibitor beta / Q15653* / Q60778* / NF-kappa-B inhibitor beta *  / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr