ENSGALG00000005653


Gallus gallus
domainNFKB2transcriptionrnapolymeraseiidna-bindingrelhomologysignalingdnabindingactivationnf-kbankyrinfactorregulationnf-kappabcomplexproximalpromotersequence-specificactivitynfkbmediatednoncanonicalnf-kappa-bdorsaldeathrepeatipt

Features
Gene ID: ENSGALG00000005653
  
Biological name :NFKB2
  
Synonyms : NFKB2 / nuclear factor NF-kappa-B p100 subunit
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 2 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653 / Q9WTK5
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 16936051
Gene end: 16944525
  
Corresponding Affymetrix probe sets: Gga.1057.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000042025
Ensembl peptide - ENSGALP00000062848
Ensembl peptide - ENSGALP00000046812
Ensembl peptide - ENSGALP00000009054
NCBI entrez gene - 386574     See in Manteia.
RefSeq - NM_204413
RefSeq Peptide - NP_989744
swissprot - A0A1L1RVJ0
swissprot - A0A1D5P2B7
swissprot - F1NGH3
swissprot - R4GIS9
Ensembl - ENSGALG00000005653
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkb2ENSDARG00000038687Danio rerio
 NFKB2ENSG00000077150Homo sapiens
 Nfkb2ENSMUSG00000025225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*ENSGALG0000001230442
REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*ENSGALG0000000784517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR000488  Death domain
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011029  Death-like domain superfamily
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR030492  Rel homology domain, conserved site
 IPR032397  Rel homology dimerisation domain


Gene Ontology (GO)
cellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular developmental processcell activationimmune responseanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscellular component organizationcellular decellular developmental processcell activacell activationimmune respimmune responseanatomical anatomical structure developmentnitrogen conitrogen compound metabolic processbiosynthetibiosynthetic processcellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processcell communcell communicationcellular recellular response to stimuluscellular cocellular component organization
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityDNA-binding transcription factor activity
cellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellorganelleprotein-containing complexcellcellorganelleorganelleprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0002268 follicular dendritic cell differentiation IEA
 biological_processGO:0002467 germinal center formation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048536 spleen development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033257 Bcl3/NF-kappaB2 complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
SUMOylation of immune response proteins
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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