ENSG00000162924


Homo sapiens

Features
Gene ID: ENSG00000162924
  
Biological name :REL
  
Synonyms : Q04864 / REL / REL proto-oncogene, NF-kB subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p16.1
Gene start: 60881521
Gene end: 60931610
  
Corresponding Affymetrix probe sets: 206035_at (Human Genome U133 Plus 2.0 Array)   206036_s_at (Human Genome U133 Plus 2.0 Array)   228812_at (Human Genome U133 Plus 2.0 Array)   235242_at (Human Genome U133 Plus 2.0 Array)   239486_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295025
Ensembl peptide - ENSP00000377989
Ensembl peptide - ENSP00000496299
NCBI entrez gene - 5966     See in Manteia.
OMIM - 164910
RefSeq - XM_017004627
RefSeq - NM_001291746
RefSeq - NM_002908
RefSeq - XM_011533010
RefSeq Peptide - NP_001278675
RefSeq Peptide - NP_002899
swissprot - Q04864
Ensembl - ENSG00000162924
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 relENSDARG00000055276Danio rerio
 RELENSGALG00000007845Gallus gallus
 RelENSMUSG00000020275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RELA / Q04206 / RELA proto-oncogene, NF-kB subunitENSG0000017303936
NFKB1 / P19838 / nuclear factor kappa B subunit 1ENSG0000010932029
RELB / Q01201 / RELB proto-oncogene, NF-kB subunitENSG0000010485628
NFKB2 / Q00653 / nuclear factor kappa B subunit 2ENSG0000007715027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030505  Proto-oncogene c-Rel
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0032688 negative regulation of interferon-beta production IDA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:1901215 negative regulation of neuron death IEA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / complex
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex / reaction
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / complex
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction






 

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