ENSG00000166167


Homo sapiens
signalingBTRCproteinregulationpathwayprocessactivitydomaindegradationwdcellcatabolicreceptorligasemediatedgliproteasomerepeatsuperfamilytransitioncycleubiquitin-dependentnf-kappabcircadiantranscriptioncomplexbindingbeta-cateninactivationnf-kb-repeat-containing

Features
Gene ID: ENSG00000166167
  
Biological name :BTRC
  
Synonyms : beta-transducin repeat containing E3 ubiquitin protein ligase / BTRC / Q9Y297
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.32
Gene start: 101354033
Gene end: 101557321
  
Corresponding Affymetrix probe sets: 1563620_at (Human Genome U133 Plus 2.0 Array)   204901_at (Human Genome U133 Plus 2.0 Array)   216091_s_at (Human Genome U133 Plus 2.0 Array)   222374_at (Human Genome U133 Plus 2.0 Array)   224471_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377088
Ensembl peptide - ENSP00000385339
Ensembl peptide - ENSP00000359202
Ensembl peptide - ENSP00000359206
NCBI entrez gene - 8945     See in Manteia.
OMIM - 603482
RefSeq - XM_017016874
RefSeq - NM_033637
RefSeq - XM_006718054
RefSeq - XM_011540320
RefSeq - XM_017016870
RefSeq - XM_017016871
RefSeq - XM_017016872
RefSeq - XM_017016873
RefSeq - NM_001256856
RefSeq - NM_003939
RefSeq Peptide - NP_001243785
RefSeq Peptide - NP_003930
RefSeq Peptide - NP_378663
swissprot - B7Z3H4
swissprot - A0A0S2Z4P6
swissprot - Q5T1W7
swissprot - Q9Y297
Ensembl - ENSG00000166167
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BTRCENSGALG00000007820Gallus gallus
 BtrcENSMUSG00000025217Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11ENSG0000007280376
FBXW7 / Q969H0 / F-box and WD repeat domain containing 7ENSG0000010967025
Q9H2Y7 / ZNF106 / zinc finger protein 106ENSG0000010399422
TRAF7 / Q6Q0C0 / TNF receptor associated factor 7ENSG0000013165319
FBXW10 / Q5XX13 / F-box and WD repeat domain containing 10ENSG0000017193117
CDRT1 / O95170 / CMT1A duplicated region transcript 1ENSG0000024132216
FBXW2 / Q9UKT8 / F-box and WD repeat domain containing 2ENSG0000011940215
WDR86 / Q86TI4 / WD repeat domain 86ENSG0000018726014


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
cell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cyclenitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processresponse to stressimmune responsecell communicationcellular response to stimuluscatabolic processinterspecies interaction between organismsregulation of biological qualityanatomical structure developmentepithelial cell proliferationcircadian rhythmbiosynthetic processregulation of molecular functionresponse to chemicalcell cycell cyclenitrogenitrogen compound metabolic processcellulacellular metabolic processprimaryprimary metabolic processorganicorganic substance metabolic processresponsresponse to stressimmune immune responsecell cocell communicationcellulacellular response to stimuluscatabolcatabolic processinterspinterspecies interaction between organismsregulatregulation of biological qualityanatomianatomical structure developmentepithelepithelial cell proliferationcircadicircadian rhythmbiosyntbiosynthetic processregulatregulation of molecular functionresponsresponse to chemical
catalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a proteintransferase activityprotein bindingligase activitycatalytic activity, acting on a procatalytic activity, acting on a proteintransferase activitytransferase activityprotein bindingprotein bindingligase activityligase activity
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006470 protein dephosphorylation ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016055 Wnt signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042752 regulation of circadian rhythm IDA
 biological_processGO:0042753 positive regulation of circadian rhythm ISS
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045862 positive regulation of proteolysis IMP
 biological_processGO:0045879 negative regulation of smoothened signaling pathway TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IC
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IDA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0045309 protein phosphorylated amino acid binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Deactivation of the beta-catenin transactivating complex
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
Abnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the eyesAbnormality of the musculoskeletal systemAbnormality of limbsAbnormality of the earsAbnormality of the earsAbnormality of the eyesAbnormality of the eyesAbnormality of the musculoskeletal Abnormality of the musculoskeletal systemAbnormality of limbsAbnormality of limbs
IDPhenotypeDefinition Genetic BG
 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
Show

 HP:0000526 Aniridia "Congenital absence of the iris." [HPO:curators]
Show

 HP:0001171 Ectrodactyly (hands) 
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 HP:0004050 Absent hands 
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 HP:0006101 Finger syndactyly "Webbing or fusion of the fingers, involving soft parts only or including bone structure. Bony fusions are revered to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are refered to as "Symphalangism"." [HPO:curators]
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 HP:0012165 Oligodactyly "A developmental defect resulting in the presence of fewer than the normal number of digits." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000134982 APC / P25054 / APC, WNT signaling pathway regulator  / complex
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / complex / reaction
 ENSG00000159692 CTBP1 / Q13363 / C-terminal binding protein 1  / complex
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / complex / reaction
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000112029 FBXO5 / Q9UKT4 / F-box protein 5  / complex / reaction
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex / reaction
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / complex / reaction
 ENSG00000105325 FZR1 / Q9UM11 / fizzy and cell division cycle 20 related 1  / complex / reaction
 ENSG00000172179 PRL / P01236 / prolactin  / complex / reaction
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / reaction
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex / reaction
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction






 

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