ENSG00000136487


Homo sapiens

Features
Gene ID: ENSG00000136487
  
Biological name :GH2
  
Synonyms : GH2 / growth hormone 2 / P01242
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q23.3
Gene start: 63880215
Gene end: 63881935
  
Corresponding Affymetrix probe sets: 206195_x_at (Human Genome U133 Plus 2.0 Array)   211151_x_at (Human Genome U133 Plus 2.0 Array)   211508_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481086
Ensembl peptide - ENSP00000394122
Ensembl peptide - ENSP00000409294
Ensembl peptide - ENSP00000410618
Ensembl peptide - ENSP00000333157
NCBI entrez gene - 2689     See in Manteia.
OMIM - 139240
RefSeq - NM_002059
RefSeq - NM_022556
RefSeq - NM_022557
RefSeq - NM_022558
RefSeq Peptide - NP_072050
RefSeq Peptide - NP_002050
RefSeq Peptide - NP_072052
RefSeq Peptide - NP_072051
swissprot - P01242
swissprot - A0A0M6L0J9
swissprot - A0A087WXJ5
Ensembl - ENSG00000136487
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gh1ENSDARG00000038185Danio rerio
 GHENSGALG00000000249Gallus gallus
 GhENSMUSG00000020713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GH1 / P01241 / growth hormone 1ENSG0000025938458
CSH1 / P0DML2 / chorionic somatomammotropin hormone 1ENSG0000013648848
CSH2 / P0DML3 / chorionic somatomammotropin hormone 2ENSG0000021321848
CSHL1 / Q14406 / chorionic somatomammotropin hormone like 1ENSG0000020441446


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031904 endosome lumen TAS
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000112964 GHR / P10912 / growth hormone receptor  / complex / reaction
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000172179 PRL / P01236 / prolactin  / complex
 ENSG00000120833 SOCS2 / O14508 / suppressor of cytokine signaling 2  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex / -
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / complex / reaction
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / - / complex
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex
 ENSG00000178188 SH2B1 / Q9NRF2 / SH2B adaptor protein 1  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / complex / reaction
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000114737 CISH / Q9NSE2 / cytokine inducible SH2 containing protein  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / complex / reaction






 

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