Manteia

ENSG00000100387

Homo sapiens

Features

Gene ID:	ENSG00000100387

Biological name :	RBX1

Synonyms :	P62877 / RBX1 / ring-box 1

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	22
Strand:	1
Band:	q13.2
Gene start:	40951347
Gene end:	40973309

Corresponding Affymetrix probe sets:	218117_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000216225 NCBI entrez gene - 9978 See in Manteia. OMIM - 603814 RefSeq - NM_014248 RefSeq Peptide - NP_055063 swissprot - P62877 Ensembl - ENSG00000100387

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rbx1	ENSDARG00000038030	Danio rerio
RBX1	ENSGALG00000011993	Gallus gallus
Rbx1	ENSMUSG00000022400	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
RNF7 / Q9UBF6 / ring finger protein 7	ENSG00000114125	47

Protein motifs (from Interpro)

Interpro ID	Name
IPR001841	Zinc finger, RING-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR024766	Zinc finger, RING-H2-type

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	TAS
biological_process	GO:0000209	protein polyubiquitination	TAS
biological_process	GO:0000715	nucleotide-excision repair, DNA damage recognition	TAS
biological_process	GO:0000717	nucleotide-excision repair, DNA duplex unwinding	TAS
biological_process	GO:0006281	DNA repair	IEA
biological_process	GO:0006283	transcription-coupled nucleotide-excision repair	TAS
biological_process	GO:0006293	nucleotide-excision repair, preincision complex stabilization	TAS
biological_process	GO:0006294	nucleotide-excision repair, preincision complex assembly	TAS
biological_process	GO:0006295	nucleotide-excision repair, DNA incision, 3"-to lesion	TAS
biological_process	GO:0006296	nucleotide-excision repair, DNA incision, 5"-to lesion	TAS
biological_process	GO:0006513	protein monoubiquitination	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0010265	SCF complex assembly	TAS
biological_process	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	TAS
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0016055	Wnt signaling pathway	TAS
biological_process	GO:0016567	protein ubiquitination	TAS
biological_process	GO:0030163	protein catabolic process	IEA
biological_process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IPI
biological_process	GO:0033683	nucleotide-excision repair, DNA incision	TAS
biological_process	GO:0042769	DNA damage response, detection of DNA damage	TAS
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IDA
biological_process	GO:0043687	post-translational protein modification	TAS
biological_process	GO:0045116	protein neddylation	IDA
biological_process	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	TAS
biological_process	GO:0070498	interleukin-1-mediated signaling pathway	TAS
biological_process	GO:0070911	global genome nucleotide-excision repair	TAS
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	TAS
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0019005	SCF ubiquitin ligase complex	IEA
cellular_component	GO:0030891	VCB complex	IEA
cellular_component	GO:0031461	cullin-RING ubiquitin ligase complex	IDA
cellular_component	GO:0031462	Cul2-RING ubiquitin ligase complex	IDA
cellular_component	GO:0031463	Cul3-RING ubiquitin ligase complex	IDA
cellular_component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	IDA
cellular_component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	IDA
cellular_component	GO:0031466	Cul5-RING ubiquitin ligase complex	IDA
cellular_component	GO:0031467	Cul7-RING ubiquitin ligase complex	IDA
cellular_component	GO:0043224	nuclear SCF ubiquitin ligase complex	IBA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IPI
molecular_function	GO:0008270	zinc ion binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019788	NEDD8 transferase activity	TAS
molecular_function	GO:0031625	ubiquitin protein ligase binding	IDA
molecular_function	GO:0034450	ubiquitin-ubiquitin ligase activity	IDA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0061630	ubiquitin protein ligase activity	IDA
molecular_function	GO:0097602	cullin family protein binding	IDA

Pathways (from Reactome)

Pathway description

Recognition of DNA damage by PCNA-containing replication complex

Prolactin receptor signaling

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Vif-mediated degradation of APOBEC3G

Degradation of beta-catenin by the destruction complex

NOTCH1 Intracellular Domain Regulates Transcription

Constitutive Signaling by NOTCH1 PEST Domain Mutants

Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling

Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants

Degradation of DVL

Degradation of GLI1 by the proteasome

Degradation of GLI2 by the proteasome

GLI3 is processed to GLI3R by the proteasome

Hedgehog on state

Regulation of RAS by GAPs

DNA Damage Recognition in GG-NER

Formation of Incision Complex in GG-NER

Dual Incision in GG-NER

Formation of TC-NER Pre-Incision Complex

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Dual incision in TC-NER

Gap-filling DNA repair synthesis and ligation in TC-NER

Orc1 removal from chromatin

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

Regulation of RUNX2 expression and activity

Neddylation

Regulation of expression of SLITs and ROBOs

Interleukin-1 signaling

Negative regulation of NOTCH4 signaling

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000004975	DVL2 / O14641 / dishevelled segment polarity protein 2	/ complex / reaction
ENSG00000100387	RBX1 / P62877 / ring-box 1	/ complex
ENSG00000100906	NFKBIA / P25963 / NFKB inhibitor alpha	/ complex / reaction
ENSG00000109320	NFKB1 / P19838 / nuclear factor kappa B subunit 1	/ complex / reaction
ENSG00000124440	HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit	/ complex / reaction
ENSG00000130725	UBE2M / P61081 / ubiquitin conjugating enzyme E2 M	/ complex / reaction
ENSG00000129559	NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8	/ complex / reaction
ENSG00000113494	PRLR / P16471 / prolactin receptor	/ complex / reaction
ENSG00000129521	EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3	/ complex
ENSG00000112659	CUL9 / Q8IWT3 / cullin 9	/ complex
ENSG00000036257	CUL3 / Q13618 / cullin 3	/ complex
ENSG00000134574	DDB2 / Q92466 / damage specific DNA binding protein 2	/ complex
ENSG00000103363	ELOB / Q15370 / elongin B	/ complex
ENSG00000134086	VHL / P40337 / von Hippel-Lindau tumor suppressor	/ complex
ENSG00000116016	EPAS1 / Q99814 / endothelial PAS domain protein 1	/ complex / reaction
ENSG00000043093	Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1	/ complex / reaction
ENSG00000173039	RELA / Q04206 / RELA proto-oncogene, NF-kB subunit	/ complex / reaction
ENSG00000154767	XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor	/ complex / reaction
ENSG00000148400	NOTCH1 / P46531	/ complex / reaction
ENSG00000154582	ELOC / Q15369 / elongin C	/ complex
ENSG00000087586	AURKA / O14965 / aurora kinase A	/ complex / reaction
ENSG00000161202	DVL3 / Q92997 / dishevelled segment polarity protein 3	/ complex / reaction
ENSG00000172179	PRL / P01236 / prolactin	/ complex / reaction
ENSG00000167986	DDB1 / Q16531 / damage specific DNA binding protein 1	/ complex
ENSG00000173163	COMMD1 / Q8N668 / copper metabolism domain containing 1	/ complex / reaction
ENSG00000144791	LIMD1 / Q9UGP4 / LIM domains containing 1	/ complex
ENSG00000100644	HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit	/ complex / reaction
ENSG00000188215	Q8IWE4 / DCUN1D3 / defective in cullin neddylation 1 domain containing 3	/ complex / reaction
ENSG00000055130	CUL1 / Q13616 / cullin 1	/ complex / reaction
ENSG00000259384	GH1 / P01241 / growth hormone 1	/ complex / reaction
ENSG00000183580	FBXL7 / Q9UJT9 / F-box and leucine rich repeat protein 7	/ complex / reaction
ENSG00000136487	GH2 / P01242 / growth hormone 2	/ complex / reaction
ENSG00000136488	CSH1 / P0DML2 / chorionic somatomammotropin hormone 1	/ complex / reaction
ENSG00000074047	GLI2 / P10070 / GLI family zinc finger 2	/ complex / reaction
ENSG00000113558	SKP1 / P63208 / S-phase kinase associated protein 1	/ complex / reaction
ENSG00000119318	P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein	/ complex / reaction
ENSG00000131778	CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 like	/ complex / reaction
ENSG00000225830	ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factor	/ complex / reaction
ENSG00000117153	KLHL12 / Q53G59 / kelch like family member 12	/ complex
ENSG00000108094	CUL2 / Q13617 / cullin 2	/ complex
ENSG00000147400	CETN2 / P41208 / centrin 2	/ complex / reaction
ENSG00000135766	EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1	/ complex
ENSG00000166266	CUL5 / Q93034 / cullin 5	/ complex
ENSG00000155034	FBXL18 / Q96ME1 / F-box and leucine rich repeat protein 18	/ complex
ENSG00000101997	CCDC22 / O60826 / coiled-coil domain containing 22	/ complex / reaction
ENSG00000120696	KBTBD7 / Q8WVZ9 / kelch repeat and BTB domain containing 7	/ complex
ENSG00000096968	JAK2 / O60674 / Janus kinase 2	/ complex / reaction
ENSG00000106571	GLI3 / P10071 / GLI family zinc finger 3	/ complex / reaction
ENSG00000111530	CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1	/ complex / reaction
ENSG00000106399	RPA3 / P35244 / replication protein A3	/ complex / reaction
ENSG00000106628	POLD2 / P49005 / DNA polymerase delta 2, accessory subunit	/ complex / reaction
ENSG00000131508	P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2	/ reaction
ENSG00000082701	GSK3B / P49841 / glycogen synthase kinase 3 beta	/ complex / reaction
ENSG00000049167	ERCC8 / Q13216 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit	/ complex
ENSG00000077514	POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit	/ complex / reaction
ENSG00000044090	CUL7 / Q14999 / cullin 7	/ complex / reaction
ENSG00000132383	RPA1 / P27694 / replication protein A1	/ complex / reaction
ENSG00000109670	FBXW7 / Q969H0 / F-box and WD repeat domain containing 7	/ complex
ENSG00000124006	OBSL1 / O75147 / obscurin like 1	/ complex / reaction
ENSG00000175482	POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit	/ complex / reaction
ENSG00000169515	CCDC8 / Q9H0W5 / coiled-coil domain containing 8	/ complex / reaction
ENSG00000117748	RPA2 / P15927 / replication protein A2	/ complex / reaction
ENSG00000145604	SKP2 / Q13309 / S-phase kinase associated protein 2	/ complex
ENSG00000184557	SOCS3 / O14543 / suppressor of cytokine signaling 3	/ complex
ENSG00000109332	P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3	/ reaction
ENSG00000158290	CUL4B / Q13620 / cullin 4B	/ complex
ENSG00000139842	CUL4A / Q13619 / cullin 4A	/ complex
ENSG00000132128	LRRC41 / Q15345 / leucine rich repeat containing 41	/ complex
ENSG00000185338	SOCS1 / O15524 / suppressor of cytokine signaling 1	/ complex
ENSG00000121022	COPS5 / Q92905 / COP9 signalosome subunit 5	/ reaction
ENSG00000121067	SPOP / O43791 / speckle type BTB/POZ protein	/ complex
ENSG00000124813	RUNX2 / Q13950 / runt related transcription factor 2	/ complex / reaction
ENSG00000143476	DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog	/ complex
ENSG00000143799	PARP1 / P09874 / poly(ADP-ribose) polymerase 1	/ complex / reaction
ENSG00000166167	BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase	/ complex
ENSG00000136936	XPA / P23025 / XPA, DNA damage recognition and repair factor	/ complex / reaction
ENSG00000072401	P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1	/ reaction
ENSG00000132646	PCNA / P12004 / proliferating cell nuclear antigen	/ complex / reaction
ENSG00000239713	Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3G	/ complex / reaction
ENSG00000062822	POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr