ENSG00000106628


Homo sapiens

Features
Gene ID: ENSG00000106628
  
Biological name :POLD2
  
Synonyms : DNA polymerase delta 2, accessory subunit / P49005 / POLD2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p13
Gene start: 44114681
Gene end: 44124358
  
Corresponding Affymetrix probe sets: 201115_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389816
Ensembl peptide - ENSP00000480186
Ensembl peptide - ENSP00000416203
Ensembl peptide - ENSP00000406702
Ensembl peptide - ENSP00000399447
Ensembl peptide - ENSP00000397461
Ensembl peptide - ENSP00000395231
Ensembl peptide - ENSP00000223361
Ensembl peptide - ENSP00000386105
NCBI entrez gene - 5425     See in Manteia.
OMIM - 600815
RefSeq - XM_011515431
RefSeq - NM_001127218
RefSeq - NM_001256879
RefSeq - NM_006230
RefSeq Peptide - NP_006221
RefSeq Peptide - NP_001120690
RefSeq Peptide - NP_001243808
swissprot - P49005
swissprot - C9JLE1
swissprot - C9J8Z7
swissprot - C9IZD2
swissprot - C9JHC7
swissprot - A0A087WWF6
swissprot - F8W8R3
swissprot - H7C1B3
Ensembl - ENSG00000106628
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pold2ENSDARG00000095046Danio rerio
 ENSGALG00000037932Gallus gallus
 Pold2ENSMUSG00000020471Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007185  DNA polymerase alpha/epsilon, subunit B
 IPR024826  DNA polymerase delta/II small subunit family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006261 DNA-dependent DNA replication IEA
 biological_processGO:0006266 DNA ligation TAS
 biological_processGO:0006271 DNA strand elongation involved in DNA replication IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0006298 mismatch repair TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0019985 translesion synthesis TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0043625 delta DNA polymerase complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003887 DNA-directed DNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / reaction / complex
 ENSG00000119048 UBE2B / P63146 / ubiquitin conjugating enzyme E2 B  / complex / reaction
 ENSG00000070950 RAD18 / Q9NS91 / RAD18, E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / reaction / complex
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction / complex
 ENSG00000168496 FEN1 / P39748 / flap structure-specific endonuclease 1  / complex / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex / reaction
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / reaction / complex
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / complex / reaction
 ENSG00000143476 DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog  / complex / reaction
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / reaction / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction / complex
 ENSG00000005156 LIG3 / P49916 / DNA ligase 3  / reaction
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / reaction
 ENSG00000105486 LIG1 / P18858 / DNA ligase 1  / complex / reaction
 ENSG00000138346 DNA2 / P51530 / DNA replication helicase/nuclease 2  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr