ENSG00000105486


Homo sapiens

Features
Gene ID: ENSG00000105486
  
Biological name :LIG1
  
Synonyms : DNA ligase 1 / LIG1 / P18858
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 48115445
Gene end: 48170603
  
Corresponding Affymetrix probe sets: 202726_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472331
Ensembl peptide - ENSP00000472085
Ensembl peptide - ENSP00000483027
Ensembl peptide - ENSP00000263274
Ensembl peptide - ENSP00000441531
Ensembl peptide - ENSP00000442841
Ensembl peptide - ENSP00000445928
Ensembl peptide - ENSP00000469638
Ensembl peptide - ENSP00000471380
Ensembl peptide - ENSP00000471836
Ensembl peptide - ENSP00000471861
NCBI entrez gene - 3978     See in Manteia.
OMIM - 126391
RefSeq - XM_017026809
RefSeq - NM_000234
RefSeq - NM_001289063
RefSeq - NM_001289064
RefSeq - NM_001320970
RefSeq - NM_001320971
RefSeq Peptide - NP_001307900
RefSeq Peptide - NP_001275993
RefSeq Peptide - NP_001307899
RefSeq Peptide - NP_000225
RefSeq Peptide - NP_001275992
swissprot - M0R0Q7
swissprot - M0R1G7
swissprot - M0R254
swissprot - M0R1S4
swissprot - P18858
swissprot - B4E135
swissprot - F5GZ28
swissprot - M0QY71
Ensembl - ENSG00000105486
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig1ENSDARG00000060041Danio rerio
 Lig1ENSMUSG00000056394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIG3 / P49916 / DNA ligase 3ENSG0000000515621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR036599  DNA ligase, ATP-dependent, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006284 base-excision repair IDA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0006298 mismatch repair TAS
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:1903461 Okazaki fragment processing involved in mitotic DNA replication IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003909 DNA ligase activity TAS
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Early Phase of HIV Life Cycle
Processive synthesis on the C-strand of the telomere
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / complex / reaction
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / complex / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / complex / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction






 

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