ENSDARG00000060041


Danio rerio

Features
Gene ID: ENSDARG00000060041
  
Biological name :lig1
  
Synonyms : lig1 / ligase I, DNA, ATP-dependent
  
Possible biological names infered from orthology : DNA ligase 1 / P18858
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 44301276
Gene end: 44344321
  
Corresponding Affymetrix probe sets: Dr.6786.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000078609
NCBI entrez gene - 556995     See in Manteia.
swissprot - B0S533
ZFIN ID - ZDB-GENE-110404-2
Ensembl - ENSDARG00000060041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIG1ENSG00000105486Homo sapiens
 Lig1ENSMUSG00000056394Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lig3 / ligase III, DNA, ATP-dependent / P49916* / DNA ligase 3*ENSDARG0000005255317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Processive synthesis on the C-strand of the telomere
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Processive synthesis on the lagging strand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003749 polb / polymerase (DNA directed), beta / P06746* / Q8K409* / DNA polymerase beta*  / complex / reaction
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction






 

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