ENSG00000005156


Homo sapiens

Features
Gene ID: ENSG00000005156
  
Biological name :LIG3
  
Synonyms : DNA ligase 3 / LIG3 / P49916
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 34980494
Gene end: 35009743
  
Corresponding Affymetrix probe sets: 1554597_at (Human Genome U133 Plus 2.0 Array)   1554599_x_at (Human Genome U133 Plus 2.0 Array)   1555169_at (Human Genome U133 Plus 2.0 Array)   204123_at (Human Genome U133 Plus 2.0 Array)   207348_s_at (Human Genome U133 Plus 2.0 Array)   229861_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468479
Ensembl peptide - ENSP00000467063
Ensembl peptide - ENSP00000467757
Ensembl peptide - ENSP00000262327
Ensembl peptide - ENSP00000367787
Ensembl peptide - ENSP00000465288
Ensembl peptide - ENSP00000466278
NCBI entrez gene - 3980     See in Manteia.
OMIM - 600940
RefSeq - XM_017024624
RefSeq - NM_002311
RefSeq - NM_013975
RefSeq - XM_005257970
RefSeq - XM_006721896
RefSeq Peptide - NP_002302
RefSeq Peptide - NP_039269
swissprot - K7ELY6
swissprot - K7ENR9
swissprot - K7EQB6
swissprot - P49916
swissprot - K7ERZ5
swissprot - K7EJR4
Ensembl - ENSG00000005156
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lig3ENSDARG00000052553Danio rerio
 LIG3ENSGALG00000002288Gallus gallus
 Lig3ENSMUSG00000020697Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LIG1 / P18858 / DNA ligase 1ENSG0000010548619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR001510  Zinc finger, PARP-type
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR031916  DNA ligase 3, BRCT domain
 IPR036420  BRCT domain superfamily
 IPR036599  DNA ligase, ATP-dependent, N-terminal domain superfamily
 IPR036957  Zinc finger, PARP-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006266 DNA ligation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006288 base-excision repair, DNA ligation IDA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling TAS
 biological_processGO:0006302 double-strand break repair IDA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0051103 DNA ligation involved in DNA repair IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0090298 negative regulation of mitochondrial DNA replication IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity TAS
 molecular_functionGO:0003910 DNA ligase (ATP) activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction
 ENSG00000122008 POLK / Q9UBT6 / DNA polymerase kappa  / reaction
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / reaction
 ENSG00000073050 XRCC1 / P18887 / X-ray repair cross complementing 1  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / reaction
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / complex / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / complex / reaction
 ENSG00000039650 PNKP / Q96T60 / polynucleotide kinase 3-phosphatase  / complex / reaction
 ENSG00000140398 NEIL1 / Q96FI4 / nei like DNA glycosylase 1  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction






 

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