ENSG00000168496


Homo sapiens

Features
Gene ID: ENSG00000168496
  
Biological name :FEN1
  
Synonyms : FEN1 / flap structure-specific endonuclease 1 / P39748
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.2
Gene start: 61792637
Gene end: 61797244
  
Corresponding Affymetrix probe sets: 204767_s_at (Human Genome U133 Plus 2.0 Array)   204768_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460402
Ensembl peptide - ENSP00000305480
Ensembl peptide - ENSP00000445692
NCBI entrez gene - 2237     See in Manteia.
OMIM - 600393
RefSeq - NM_004111
RefSeq Peptide - NP_004102
swissprot - Q6FHX6
swissprot - F5H1Y3
swissprot - I3L3E9
swissprot - P39748
Ensembl - ENSG00000168496
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fen1ENSDARG00000011404Danio rerio
 FEN1ENSGALG00000033781Gallus gallus
 Fen1ENSMUSG00000024742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GEN1 / Q17RS7 / GEN1, Holliday junction 5 flap endonucleaseENSG0000017829524


Protein motifs (from Interpro)
Interpro ID Name
 IPR006084  XPG/Rad2 endonuclease
 IPR006085  XPG N-terminal
 IPR006086  XPG-I domain
 IPR008918  Helix-hairpin-helix motif, class 2
 IPR019974  XPG conserved site
 IPR023426  Flap endonuclease 1
 IPR029060  PIN-like domain superfamily
 IPR036279  5"-3" exonuclease, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006302 double-strand break repair TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0009650 UV protection TAS
 biological_processGO:0032201 telomere maintenance via semi-conservative replication TAS
 biological_processGO:0043137 DNA replication, removal of RNA primer IEA
 biological_processGO:0045876 positive regulation of sister chromatid cohesion IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding TAS
 molecular_functionGO:0003690 double-stranded DNA binding TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity TAS
 molecular_functionGO:0004523 RNA-DNA hybrid ribonuclease activity IDA
 molecular_functionGO:0004527 exonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008309 double-stranded DNA exodeoxyribonuclease activity TAS
 molecular_functionGO:0008409 5"-3" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds IEA
 molecular_functionGO:0017108 5"-flap endonuclease activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048256 flap endonuclease activity IDA


Pathways (from Reactome)
Pathway description
POLB-Dependent Long Patch Base Excision Repair
Early Phase of HIV Life Cycle
Removal of the Flap Intermediate from the C-strand
PCNA-Dependent Long Patch Base Excision Repair
HDR through MMEJ (alt-NHEJ)
Removal of the Flap Intermediate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / complex / reaction
 ENSG00000100823 APEX1 / P27695 / apurinic/apyrimidinic endodeoxyribonuclease 1  / complex / reaction
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / complex / reaction
 ENSG00000051341 POLQ / O75417 / DNA polymerase theta  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000014138 POLA2 / Q14181 / DNA polymerase alpha 2, accessory subunit  / reaction
 ENSG00000070501 POLB / P06746 / DNA polymerase beta  / complex / reaction
 ENSG00000146143 PRIM2 / P49643 / DNA primase subunit 2  / reaction
 ENSG00000198056 PRIM1 / P49642 / DNA primase subunit 1  / reaction
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000101773 RBBP8 / Q99708 / RB binding protein 8, endonuclease  / complex / reaction
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / complex / reaction
 ENSG00000101868 POLA1 / P09884 / DNA polymerase alpha 1, catalytic subunit  / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / complex / reaction
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / complex / reaction
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction






 

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