ENSGALG00000011993


Gallus gallus

Features
Gene ID: ENSGALG00000011993
  
Biological name :RBX1
  
Synonyms : RBX1 / ring-box 1
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877 / P62878
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 49895082
Gene end: 49906115
  
Corresponding Affymetrix probe sets: Gga.1476.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019539
Ensembl peptide - ENSGALP00000057540
NCBI entrez gene - 418001     See in Manteia.
RefSeq - NM_001199250
RefSeq Peptide - NP_001186179
swissprot - E1BSR9
swissprot - A0A1D5PX48
Ensembl - ENSGALG00000011993
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbx1ENSDARG00000038030Danio rerio
 RBX1ENSG00000100387Homo sapiens
 Rbx1ENSMUSG00000022400Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RNF7 / RING-box protein 2 / Q9WTZ1* / Gm7075* / Q9UBF6* / ring finger protein 7*ENSGALG0000002111744


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR024766  Zinc finger, RING-H2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045116 protein neddylation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IEA
 cellular_componentGO:0043224 nuclear SCF ubiquitin ligase complex IBA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019788 NEDD8 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA
 molecular_functionGO:0097602 cullin family protein binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Degradation of beta-catenin by the destruction complex
Degradation of DVL
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004611 FBXL18 / F-box and leucine rich repeat protein 18 / Q96ME1*  / complex
 ENSGALG00000008559 CUL4B / cullin 4B / A2A432* / Q13620*  / complex
 ENSGALG00000006254 ERCC6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*  / complex / reaction
 ENSGALG00000007095 CUL2 / cullin-2 / Q13617* / Q9D4H8*  / complex
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / complex / reaction
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex / reaction
 ENSGALG00000005108 CUL3 / cullin 3 / Q13618* / Q9JLV5*  / complex
 ENSGALG00000008931 COMMD1 / copper metabolism domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 *  / complex
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000009939 SPOP / speckle type BTB/POZ protein / Gm5286* / Gm5773* / Gm9117* / Gm9125* / Tdpoz5* / Gm4778* / Gm4858* / O43791* / P0DMR5* / P0DMR6* / Q6YCH2* / Q6ZWS8* / Q717B2* / Q717B4* / Tdpoz1* / T...  / complex
 ENSGALG00000021213 UBE2D1 / ubiquitin conjugating enzyme E2 D1 / P51668* / P61080*  / reaction
 ENSGALG00000011630 GLI2 / GLI family zinc finger 2 / P10070* / Q0VGT2* / Zinc finger protein GLI2 *  / complex / reaction
 ENSGALG00000014732 ERCC8 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit / Q13216* / Q8CFD5* / DNA excision repair protein ERCC-8 *  / complex
 ENSGALG00000009837 DTL / Q5ZJW8 / Denticleless protein homolog / Q3TLR7* / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / complex
 ENSGALG00000000249 GH / P08998 / Somatotropin / GH2* / GH1* / CSH1* / CSH2* / CSHL1* / Q14406* / P0DML3* / P0DML2* / P01241* / P01242* / P06880* / growth hormone 1* / growth hormone 2* / chorionic somatomamm...  / complex / reaction
 ENSGALG00000000518 KLHL12 / kelch like family member 12 / Q53G59* / Q8BZM0* / Kelch-like protein 12 *  / complex
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / complex / reaction
 ENSGALG00000002267 DCUN1D3 / defective in cullin neddylation 1 domain containing 3 / Q8IWE4* / Q8K0V2* / DCN1-like protein 3 *  / complex / reaction
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / complex / reaction
 ENSGALG00000008218 DDB2 / Q5ZJL7 / DNA damage-binding protein 2 / Q92466* / Q99J79* / damage specific DNA binding protein 2*  / complex
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / complex / reaction
 ENSGALG00000010001 EGLN3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex
 ENSGALG00000010005 EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *  / complex
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000012671 prl / P14676 / Prolactin / P04095* / P04768* / P04769* / P06879* / P09586* / Prl2a1* / Prl2b1* / Prl2c1* / Prl2c2* / Prl2c3* / Prl2c5* / Prl3a1* / Prl3b1* / Prl3c1* / Prl3d1* / Prl3d2* / P...  / complex / reaction
 ENSGALG00000007768 AURKA / aurora kinase A / O14965* / P97477*  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000042333 DDB1 / Q805F9 / DNA damage-binding protein 1 / Q16531* / Q3U1J4* / damage specific DNA binding protein 1*  / complex
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000040266 GLI3 / GLI family zinc finger 3 / P10071* / Q61602* / Transcriptional activator GLI3 Transcriptional repressor GLI3R*  / complex / reaction
 ENSGALG00000038128 UBE2D2 / ubiquitin conjugating enzyme E2 D2 / P62838* / P62837* / Ube2d2a* / ubiquitin-conjugating enzyme E2D 2A*  / reaction
 ENSGALG00000040276 RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*  / complex / reaction






 

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