ENSGALG00000010005


Gallus gallus

Features
Gene ID: ENSGALG00000010005
  
Biological name :EPAS1
  
Synonyms : endothelial PAS domain protein 1 / EPAS1
  
Possible biological names infered from orthology : Endothelial PAS domain-containing protein 1 / P97481 / Q99814
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 26625940
Gene end: 26701895
  
Corresponding Affymetrix probe sets: Gga.3035.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054997
Ensembl peptide - ENSGALP00000058033
Ensembl peptide - ENSGALP00000056872
Ensembl peptide - ENSGALP00000016234
NCBI entrez gene - 395596     See in Manteia.
RefSeq - NM_204807
RefSeq - XM_015283619
RefSeq - XM_015283618
RefSeq Peptide - NP_990138
swissprot - A0A1D5PVB0
swissprot - Q9W7C6
swissprot - F1NG41
swissprot - A0A1D5PQ37
Ensembl - ENSGALG00000010005
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 epas1aENSDARG00000008697Danio rerio
 epas1bENSDARG00000057671Danio rerio
 EPAS1ENSG00000116016Homo sapiens
 Epas1ENSMUSG00000024140Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HIF1A / hypoxia-inducible factor 1-alpha / Q16665* / Q61221* / hypoxia inducible factor 1 alpha subunit*ENSGALG0000001187045
NPAS3 / neuronal PAS domain protein 3 / Q8IXF0*ENSGALG0000002902221
SIM1 / single-minded family bHLH transcription factor 1 / P81133* / Q61045* / Single-minded homolog 1 *ENSGALG0000001546620
SIM2 / single-minded family bHLH transcription factor 2 / Q14190* / Q61079* / Single-minded homolog 2 *ENSGALG0000001604420
CLOCK / circadian locomoter output cycles protein kaput isoform 1 / O08785* / O15516* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSGALG0000001379316
ARNT / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*ENSGALG0000000075114
ARNT2 / aryl hydrocarbon receptor nuclear translocator 2 / Q61324* / Q9HBZ2*ENSGALG0000000644514
ARNTL / Q9I8T7 / Aryl hydrocarbon receptor nuclear translocator-like protein 1 / Q9WTL8* / O00327* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon re...ENSGALG0000000537813
ARNTL2 / aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q2VPD4* / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSGALG0000001409613
NPAS2 / neuronal PAS domain-containing protein 2 / Q99743* / neuronal PAS domain protein 2*ENSGALG0000001677413
ENSGALG0000000906312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR014887  HIF-1 alpha, transactivation domain, C-terminal
 IPR021537  Hypoxia-inducible factor, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0042415 norepinephrine metabolic process IEA
 biological_processGO:0043129 surfactant homeostasis IEA
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048625 myoblast fate commitment IEA
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007095 CUL2 / cullin-2 / Q13617* / Q9D4H8*  / complex
 ENSGALG00000005698 HIF1AN / hypoxia inducible factor 1 alpha subunit inhibitor / Q8BLR9* / Q9NWT6* / Hypoxia-inducible factor 1-alpha inhibitor *  / reaction
 ENSGALG00000010001 EGLN3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000021213 UBE2D1 / ubiquitin conjugating enzyme E2 D1 / P51668* / P61080*  / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / complex
 ENSGALG00000038128 UBE2D2 / ubiquitin conjugating enzyme E2 D2 / P62838* / P62837* / Ube2d2a* / ubiquitin-conjugating enzyme E2D 2A*  / reaction






 

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