ENSGALG00000011870


Gallus gallus

Features
Gene ID: ENSGALG00000011870
  
Biological name :HIF1A
  
Synonyms : HIF1A / hypoxia-inducible factor 1-alpha
  
Possible biological names infered from orthology : hypoxia inducible factor 1 alpha subunit / Q16665 / Q61221
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 54055991
Gene end: 54086580
  
Corresponding Affymetrix probe sets: Gga.4933.1.S1_at (Chicken Array)   GgaAffx.20307.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019338
NCBI entrez gene - 374177     See in Manteia.
RefSeq - XM_015287266
RefSeq - NM_204297
RefSeq - XM_015287264
RefSeq - XM_015287265
RefSeq - XM_015287262
RefSeq Peptide - NP_989628
swissprot - F1NJK2
Ensembl - ENSGALG00000011870
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hif1aaENSDARG00000006181Danio rerio
 hif1abENSDARG00000034293Danio rerio
 HIF1AENSG00000100644Homo sapiens
 Hif1aENSMUSG00000021109Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *ENSGALG0000001000548
NPAS3 / neuronal PAS domain protein 3 / Q8IXF0*ENSGALG0000002902224
SIM1 / single-minded family bHLH transcription factor 1 / P81133* / Q61045* / Single-minded homolog 1 *ENSGALG0000001546622
SIM2 / single-minded family bHLH transcription factor 2 / Q14190* / Q61079* / Single-minded homolog 2 *ENSGALG0000001604422
CLOCK / circadian locomoter output cycles protein kaput isoform 1 / O08785* / O15516* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSGALG0000001379317
ARNT / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*ENSGALG0000000075116
ARNTL / Q9I8T7 / Aryl hydrocarbon receptor nuclear translocator-like protein 1 / Q9WTL8* / O00327* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon re...ENSGALG0000000537815
ARNT2 / aryl hydrocarbon receptor nuclear translocator 2 / Q61324* / Q9HBZ2*ENSGALG0000000644515
ARNTL2 / aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q2VPD4* / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSGALG0000001409614
NPAS2 / neuronal PAS domain-containing protein 2 / Q99743* / neuronal PAS domain protein 2*ENSGALG0000001677414
ENSGALG0000000906312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001321  Hypoxia-inducible factor-1 alpha
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR014887  HIF-1 alpha, transactivation domain, C-terminal
 IPR021537  Hypoxia-inducible factor, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001837 epithelial to mesenchymal transition IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001922 B-1 B cell homeostasis IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002248 connective tissue replacement involved in inflammatory response wound healing IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003208 cardiac ventricle morphogenesis IEA
 biological_processGO:0006089 lactate metabolic process IEA
 biological_processGO:0006110 regulation of glycolytic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010573 vascular endothelial growth factor production IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0019896 axonal transport of mitochondrion IEA
 biological_processGO:0021502 neural fold elevation formation IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0032364 oxygen homeostasis IEA
 biological_processGO:0032909 regulation of transforming growth factor beta2 production IEA
 biological_processGO:0032963 collagen metabolic process IEA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042541 hemoglobin biosynthetic process IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IEA
 biological_processGO:0046886 positive regulation of hormone biosynthetic process IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051541 elastin metabolic process IEA
 biological_processGO:0060574 intestinal epithelial cell maturation IEA
 biological_processGO:0061030 epithelial cell differentiation involved in mammary gland alveolus development IEA
 biological_processGO:0061072 iris morphogenesis IEA
 biological_processGO:0061298 retina vasculature development in camera-type eye IEA
 biological_processGO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 biological_processGO:0070243 regulation of thymocyte apoptotic process IEA
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IEA
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1903715 regulation of aerobic respiration IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001054 negative regulation of mesenchymal cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0000989 transcription factor activity, transcription factor binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Ub-specific processing proteases
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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