ENSGALG00000010001


Gallus gallus

Features
Gene ID: ENSGALG00000010001
  
Biological name :EGLN3
  
Synonyms : egl-9 family hypoxia inducible factor 3 / EGLN3
  
Possible biological names infered from orthology : Q9H6Z9
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 35742881
Gene end: 35767270
  
Corresponding Affymetrix probe sets: Gga.10797.1.A1_at (Chicken Array)   Gga.10797.1.S1_at (Chicken Array)   Gga.11832.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016230
Ensembl peptide - ENSGALP00000047494
NCBI entrez gene - 423316     See in Manteia.
RefSeq - XM_421233
swissprot - A0A1D5P486
swissprot - E1C8C0
Ensembl - ENSGALG00000010001
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egln3ENSDARG00000032553Danio rerio
 EGLN3ENSG00000129521Homo sapiens
 Egln3ENSMUSG00000035105Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EGLN1 / egl-9 family hypoxia inducible factor 1 / Q91YE3* / Q9GZT9* / Egl nine homolog 1 *ENSGALG0000004142237


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0018126 protein hydroxylation IEA
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007095 CUL2 / cullin-2 / Q13617* / Q9D4H8*  / complex
 ENSGALG00000010005 EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000021213 UBE2D1 / ubiquitin conjugating enzyme E2 D1 / P51668* / P61080*  / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / complex
 ENSGALG00000038128 UBE2D2 / ubiquitin conjugating enzyme E2 D2 / P62838* / P62837* / Ube2d2a* / ubiquitin-conjugating enzyme E2D 2A*  / reaction






 

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