ENSGALG00000000249


Gallus gallus

Features
Gene ID: ENSGALG00000000249
  
Biological name :GH
  
Synonyms : GH / P08998 / Somatotropin
  
Possible biological names infered from orthology : chorionic somatomammotropin hormone 1 / chorionic somatomammotropin hormone 2 / chorionic somatomammotropin hormone like 1 / CSH1 / CSH2 / CSHL1 / GH1 / GH2 / growth hormone 1 / growth hormone 2 / P01241 / P01242 / P06880 / P0DML2 / P0DML3 / Q14406
  
Species: Gallus gallus
  
Chr. number: 27
Strand: -1
Band:
Gene start: 1787645
Gene end: 1791152
  
Corresponding Affymetrix probe sets: Gga.1267.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053450
Ensembl peptide - ENSGALP00000000327
NCBI entrez gene - 378781     See in Manteia.
RefSeq - NM_204359
RefSeq Peptide - NP_989690
swissprot - P08998
swissprot - A0A1D5PKT7
Ensembl - ENSGALG00000000249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gh1ENSDARG00000038185Danio rerio
 CSH1ENSG00000136488Homo sapiens
 CSH2ENSG00000213218Homo sapiens
 CSHL1ENSG00000204414Homo sapiens
 GH1ENSG00000259384Homo sapiens
 GH2ENSG00000136487Homo sapiens
 GhENSMUSG00000020713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0035846 oviduct epithelium development IDA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0050691 regulation of defense response to virus by host IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0005131 growth hormone receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097153 cysteine-type endopeptidase activity involved in apoptotic process IDA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Synthesis, secretion, and deacylation of Ghrelin
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000249 GH / P08998 / Somatotropin / GH2* / GH1* / CSH1* / CSH2* / CSHL1* / Q14406* / P0DML3* / P0DML2* / P01241* / P01242* / P06880* / growth hormone 1* / growth hormone 2* / chorionic somatomamm...  / - / complex
 ENSGALG00000003282 STAT5B / signal transducer and activator of transcription 5B / P42229* / P42232* / P51692* / P42230* / STAT5A* / signal transducer and activator of transcription 5A*  / complex
 ENSGALG00000014855 GHR / growth hormone receptor precursor / P16882* / P10912* / growth hormone receptor* / Growth hormone receptor Growth hormone-binding protein*  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000012671 prl / P14676 / Prolactin / P04095* / P04768* / P04769* / P06879* / P09586* / Prl2a1* / Prl2b1* / Prl2c1* / Prl2c2* / Prl2c3* / Prl2c5* / Prl3a1* / Prl3b1* / Prl3c1* / Prl3d1* / Prl3d2* / P...  / complex
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / complex / reaction
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex






 

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