Manteia

ENSG00000004975

Homo sapiens

Features

Gene ID:	ENSG00000004975

Biological name :	DVL2

Synonyms :	dishevelled segment polarity protein 2 / DVL2 / O14641

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	-1
Band:	p13.1
Gene start:	7225341
Gene end:	7234545

Corresponding Affymetrix probe sets:	218759_at (Human Genome U133 Plus 2.0 Array) 57532_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000458209 Ensembl peptide - ENSP00000459797 Ensembl peptide - ENSP00000459991 Ensembl peptide - ENSP00000005340 Ensembl peptide - ENSP00000458465 NCBI entrez gene - 1856 See in Manteia. OMIM - 602151 RefSeq - XM_017024298 RefSeq - NM_004422 RefSeq - XM_005256502 RefSeq Peptide - NP_004413 swissprot - I3L2W9 swissprot - I3L0M7 swissprot - O14641 swissprot - I3L0Z8 swissprot - I3L2N2 Ensembl - ENSG00000004975

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dvl2	ENSDARG00000056184	Danio rerio
Dvl2	ENSMUSG00000020888	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
DVL3 / Q92997 / dishevelled segment polarity protein 3	ENSG00000161202	69
DVL1 / O14640 / dishevelled segment polarity protein 1	ENSG00000107404	58
DIXDC1 / Q155Q3 / DIX domain containing 1	ENSG00000150764	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000591	DEP domain
IPR001158	DIX domain
IPR001478	PDZ domain
IPR003351	Dishevelled protein domain
IPR008339	Dishevelled family
IPR008341	Dishevelled-2
IPR015506	Dishevelled-related protein
IPR024580	Dishevelled C-terminal
IPR029071	Ubiquitin-like domain superfamily
IPR036034	PDZ superfamily
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036390	Winged helix DNA-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001843	neural tube closure	IEA
biological_process	GO:0001934	positive regulation of protein phosphorylation	IMP
biological_process	GO:0003007	heart morphogenesis	IEA
biological_process	GO:0003151	outflow tract morphogenesis	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IDA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007379	segment specification	IEA
biological_process	GO:0007507	heart development	IEA
biological_process	GO:0016055	Wnt signaling pathway	IEA
biological_process	GO:0022007	convergent extension involved in neural plate elongation	IEA
biological_process	GO:0034613	cellular protein localization	IEA
biological_process	GO:0035282	segmentation	IEA
biological_process	GO:0035329	hippo signaling	TAS
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0035567	non-canonical Wnt signaling pathway	IMP
biological_process	GO:0043507	positive regulation of JUN kinase activity	IEA
biological_process	GO:0043547	positive regulation of GTPase activity	IEA
biological_process	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation	IDA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA
biological_process	GO:0051259	protein complex oligomerization	IEA
biological_process	GO:0060029	convergent extension involved in organogenesis	IEA
biological_process	GO:0060070	canonical Wnt signaling pathway	IEA
biological_process	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	IEA
biological_process	GO:0061024	membrane organization	TAS
biological_process	GO:0061098	positive regulation of protein tyrosine kinase activity	IEA
biological_process	GO:0090090	negative regulation of canonical Wnt signaling pathway	TAS
biological_process	GO:0090103	cochlea morphogenesis	IEA
biological_process	GO:0090179	planar cell polarity pathway involved in neural tube closure	IEA
biological_process	GO:0090263	positive regulation of canonical Wnt signaling pathway	IEA
biological_process	GO:0150012	positive regulation of neuron projection arborization	IEA
biological_process	GO:1904886	beta-catenin destruction complex disassembly	TAS
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	ISS
cellular_component	GO:0005654	nucleoplasm	IDA
cellular_component	GO:0005737	cytoplasm	IDA
cellular_component	GO:0005829	cytosol	IBA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016235	aggresome	IDA
cellular_component	GO:0016328	lateral plasma membrane	IEA
cellular_component	GO:0016604	nuclear body	IDA
cellular_component	GO:0030136	clathrin-coated vesicle	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IDA
cellular_component	GO:0045177	apical part of cell	IEA
cellular_component	GO:0045334	clathrin-coated endocytic vesicle	TAS
molecular_function	GO:0005109	frizzled binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0019901	protein kinase binding	IEA
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0030674	protein binding, bridging	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0043621	protein self-association	IEA
molecular_function	GO:0048365	Rac GTPase binding	IEA

Pathways (from Reactome)

Pathway description

TCF dependent signaling in response to WNT

WNT mediated activation of DVL

Signaling by Hippo

PCP/CE pathway

Asymmetric localization of PCP proteins

Degradation of DVL

Disassembly of the destruction complex and recruitment of AXIN to the membrane

WNT5A-dependent internalization of FZD4

Negative regulation of TCF-dependent signaling by DVL-interacting proteins

RHO GTPases Activate Formins

Cargo recognition for clathrin-mediated endocytosis

Clathrin-mediated endocytosis

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000100387	RBX1 / P62877 / ring-box 1	/ complex / reaction
ENSG00000114251	WNT5A / P41221 / Wnt family member 5A	/ complex / reaction
ENSG00000108854	Q9HAU4 / SMURF2 / SMAD specific E3 ubiquitin protein ligase 2	/ complex / reaction
ENSG00000042753	AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit	/ complex / reaction
ENSG00000107242	O14986 / PIP5K1B / phosphatidylinositol-4-phosphate 5-kinase type 1 beta	/ complex / reaction
ENSG00000070018	LRP6 / O75581 / LDL receptor related protein 6	/ complex / reaction
ENSG00000036257	CUL3 / Q13618 / cullin 3	/ complex / reaction
ENSG00000157240	FZD1 / Q9UP38 / frizzled class receptor 1	/ complex / reaction
ENSG00000154342	WNT3A / P56704 / Wnt family member 3A	/ complex / reaction
ENSG00000125084	WNT1 / P04628 / Wnt family member 1	/ complex / reaction
ENSG00000155760	FZD7 / O75084 / frizzled class receptor 7	/ complex / reaction
ENSG00000161203	AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit	/ complex / reaction
ENSG00000141480	ARRB2 / P32121 / arrestin beta 2	/ complex / reaction
ENSG00000141367	CLTC / Q00610 / clathrin heavy chain	/ complex / reaction
ENSG00000015133	Q9P219 / CCDC88C / coiled-coil domain containing 88C	/ complex / reaction
ENSG00000183020	AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit	/ complex / reaction
ENSG00000180340	FZD2 / Q14332 / frizzled class receptor 2	/ complex / reaction
ENSG00000085741	WNT11 / O96014 / Wnt family member 11	/ complex / reaction
ENSG00000075290	WNT8B / Q93098 / Wnt family member 8B	/ complex / reaction
ENSG00000136238	RAC1 / P63000 / Rac family small GTPase 1	/ complex / reaction
ENSG00000196961	AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit	/ complex / reaction
ENSG00000100592	DAAM1 / Q9Y4D1 / dishevelled associated activator of morphogenesis 1	/ complex / reaction
ENSG00000198742	Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1	/ complex / reaction
ENSG00000137486	ARRB1 / P49407 / arrestin beta 1	/ complex / reaction
ENSG00000061492	WNT8A / Q9H1J5 / Wnt family member 8A	/ complex / reaction
ENSG00000117153	KLHL12 / Q53G59 / kelch like family member 12	/ complex / reaction
ENSG00000174804	FZD4 / Q9ULV1 / frizzled class receptor 4	/ complex / reaction
ENSG00000006125	AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit	/ complex / reaction
ENSG00000102981	PARD6A / Q9NPB6 / par-6 family cell polarity regulator alpha	/ complex
ENSG00000101266	P68400 / CSNK2A1 / casein kinase 2 alpha 1	/ reaction
ENSG00000108518	PFN1 / P07737 / profilin 1	/ complex / reaction
ENSG00000082701	GSK3B / P49841 / glycogen synthase kinase 3 beta	/ complex / reaction
ENSG00000103126	AXIN1 / O15169	/ complex / reaction
ENSG00000070770	P19784 / CSNK2A2 / casein kinase 2 alpha 2	/ reaction
ENSG00000067560	RHOA / P61586 / ras homolog family member A	/ complex / reaction
ENSG00000165617	DACT1 / Q9NYF0 / dishevelled binding antagonist of beta catenin 1	/ complex / reaction
ENSG00000213923	CSNK1E / P49674 / casein kinase 1 epsilon	/ reaction
ENSG00000018408	WWTR1 / Q9GZV5 / WW domain containing transcription regulator 1	/ complex / reaction
ENSG00000204435	CSNK2B / P67870 / casein kinase 2 beta	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr