ENSMUSG00000053113


Mus musculus

Features
Gene ID: ENSMUSG00000053113
  
Biological name :Socs3
  
Synonyms : O35718 / Socs3 / suppressor of cytokine signaling 3
  
Possible biological names infered from orthology : O14543
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 117966079
Gene end: 117970047
  
Corresponding Affymetrix probe sets: 10393449 (MoGene1.0st)   1416576_at (Mouse Genome 430 2.0 Array)   1455899_x_at (Mouse Genome 430 2.0 Array)   1456212_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059129
NCBI entrez gene - 12702     See in Manteia.
MGI - MGI:1201791
RefSeq - NM_007707
RefSeq - XM_011248707
RefSeq Peptide - NP_031733
swissprot - O35718
Ensembl - ENSMUSG00000053113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs3aENSDARG00000025428Danio rerio
 socs3bENSDARG00000026611Danio rerio
 SOCS3ENSGALG00000027786Gallus gallus
 SOCS3ENSG00000184557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cish / Q62225 / Cytokine-inducible SH2-containing protein / Q9NSE2*ENSMUSG0000003257831
Socs2 / O35717 / suppressor of cytokine signaling 2 / O14508*ENSMUSG0000002002726
Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*ENSMUSG0000003803726
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848522
Socs4 / Q91ZA6 / Suppressor of cytokine signaling 4 / Q8WXH5*ENSMUSG0000004837922
Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*ENSMUSG0000005615322
Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*ENSMUSG0000003710421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028414  Suppressor of cytokine signalling 3
 IPR035863  SOCS3, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0009968 negative regulation of signal transduction IGI
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045597 positive regulation of cell differentiation IGI
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IDA
 biological_processGO:0050728 negative regulation of inflammatory response IGI
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0060674 placenta blood vessel development IMP
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 biological_processGO:0060708 spongiotrophoblast differentiation IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0001784 phosphotyrosine residue binding IMP
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
Interferon gamma signaling
Regulation of IFNG signaling
PTK6 Activates STAT3
Neddylation
Interferon alpha/beta signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Socs3tm1Robb/Socs3tm1Robb
Genetic Background: involves: C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Socs3tm1Robb/Socs3tm1Robb
Genetic Background: involves: C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0001711 abnormal placenta 
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Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mostm1Sia/Mostm1Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: B6.129S2-H2-Ab1tm1Gru

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp3tm5.2Ayr/Foxp3tm5.2Ayr
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: B6.129P2-Socs3tm1Jni

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Socs3tm1Robb/Socs3tm1Robb
Genetic Background: involves: C57BL/6

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: B6.129P2-Socs3tm1Jni

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: B6.129P2-Socs3tm1Jni

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs3tm1Robb/Socs3tm1Robb
Genetic Background: involves: C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009397 increased trophoblast giant cell number "greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs3tm1Jni/Socs3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ifngtm1Ts/Ifngtm1Ts,Socs1tm1Jni/Socs1tm1Jni
Genetic Background: involves: 129S7/SvEvBrd

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Socs3tm1Wsa/Socs3tm1Wsa
Genetic Background: either: C57BL/6-Socs3tm1Wsa or (involves: 129/Sv * C57BL/6)

 MP:0012100 absent spongiotrophoblast "absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Acacbtm1.1Dejs/Acacbtm1.1Dejs
Genetic Background: B6.Cg-Acacbtm1.1Dejs

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Socs3tm1Ayos/Socs3tm1Ayos,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000025746 Il6 / P08505 / interleukin 6 / P05231*  / complex / reaction
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / complex / reaction
 ENSMUSG00000032030 Cul5 / cullin 5 / Q93034*  / complex
 ENSMUSG00000027947 Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*  / complex / reaction
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000020009 Ifngr1 / P15261 / interferon gamma receptor 1 / P15260*  / complex / reaction
 ENSMUSG00000022967 Ifnar1 / P33896 / Interferon alpha/beta receptor 1 / P17181* / interferon alpha and beta receptor subunit 1*  / complex
 ENSMUSG00000022971 O35664 / Ifnar2 / interferon (alpha and beta) receptor 2 / P48551* / AP000295.1* / interferon alpha and beta receptor subunit 2*  / complex
 ENSMUSG00000022965 Ifngr2 / interferon gamma receptor 2 / P38484*  / complex / reaction
 ENSMUSG00000055737 Ghr / P16882 / Growth hormone receptor Growth hormone-binding protein / P10912* / growth hormone receptor*  / complex / reaction
 ENSMUSG00000048806 Ifnb1 / P01575 / interferon beta 1, fibroblast / P01574* / interferon beta 1*  / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex / reaction
 ENSMUSG00000055170 Ifng / P01580 / Interferon gamma / P01579*  / complex / reaction
 ENSMUSG00000040033 Stat2 / signal transducer and activator of transcription 2 / P52630*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex / reaction
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / complex / reaction
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / complex / reaction
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex






 

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