ENSMUSG00000020027


Mus musculus

Features
Gene ID: ENSMUSG00000020027
  
Biological name :Socs2
  
Synonyms : O35717 / Socs2 / suppressor of cytokine signaling 2
  
Possible biological names infered from orthology : O14508
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 95385362
Gene end: 95417180
  
Corresponding Affymetrix probe sets: 10372069 (MoGene1.0st)   10394674 (MoGene1.0st)   1418507_s_at (Mouse Genome 430 2.0 Array)   1438470_at (Mouse Genome 430 2.0 Array)   1441476_at (Mouse Genome 430 2.0 Array)   1442586_at (Mouse Genome 430 2.0 Array)   1446085_at (Mouse Genome 430 2.0 Array)   1449109_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121305
Ensembl peptide - ENSMUSP00000118720
Ensembl peptide - ENSMUSP00000129331
Ensembl peptide - ENSMUSP00000131875
Ensembl peptide - ENSMUSP00000020215
Ensembl peptide - ENSMUSP00000113378
Ensembl peptide - ENSMUSP00000117576
Ensembl peptide - ENSMUSP00000117785
NCBI entrez gene - 216233     See in Manteia.
MGI - MGI:1201787
RefSeq - XM_017313902
RefSeq - NM_001168655
RefSeq - NM_001168656
RefSeq - NM_001168657
RefSeq - NM_007706
RefSeq - XM_006513515
RefSeq - XM_006513517
RefSeq - XM_011243406
RefSeq - XM_011243410
RefSeq - XM_017313901
RefSeq Peptide - NP_001162128
RefSeq Peptide - NP_031732
RefSeq Peptide - NP_001162126
RefSeq Peptide - NP_001162127
swissprot - D3YZ26
swissprot - O35717
swissprot - Q548Q7
swissprot - D3Z441
swissprot - F6RVG2
swissprot - D3Z355
Ensembl - ENSMUSG00000020027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 socs2ENSDARG00000045557Danio rerio
 SOCS2ENSGALG00000011295Gallus gallus
 SOCS2ENSG00000120833Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cish / Q62225 / Cytokine-inducible SH2-containing protein / Q9NSE2*ENSMUSG0000003257842
Socs6 / Q9JLY0 / Suppressor of cytokine signaling 6 / O14544*ENSMUSG0000005615330
Socs5 / O54928 / Suppressor of cytokine signaling 5 / O75159*ENSMUSG0000003710429
Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*ENSMUSG0000005311329
Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*ENSMUSG0000003803728
Socs7 / Q8VHQ2 / Suppressor of cytokine signaling 7 / O14512*ENSMUSG0000003848528
Socs4 / Q91ZA6 / Suppressor of cytokine signaling 4 / Q8WXH5*ENSMUSG0000004837927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001496  SOCS box domain
 IPR028410  Suppressor of cytokine signalling 2
 IPR035862  SOCS2, SH2 domain
 IPR036036  SOCS box-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0032355 response to estradiol ISO
 biological_processGO:0032870 cellular response to hormone stimulus ISO
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0040015 negative regulation of multicellular organism growth IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IGI
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0060396 growth hormone receptor signaling pathway ISO
 biological_processGO:0060749 mammary gland alveolus development IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005131 growth hormone receptor binding IPI
 molecular_functionGO:0005159 insulin-like growth factor receptor binding ISS
 molecular_functionGO:0008269 JAK pathway signal transduction adaptor activity IEA


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Myo5argsc705/Myo5argsc705
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Myo5argsc705/Myo5argsc705
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

Allelic Composition: Socs2tm1Wehi/Socs2+
Genetic Background: C57BL/6-Socs2tm1Wehi

Allelic Composition: Socs2m1Btlr/Socs2m1Btlr
Genetic Background: C57BL/6J-Socs2m1Btlr

Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002138 abnormal liver/biliary system morphology "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myo5argsc705/Myo5argsc705
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Bbs4Gt1Nk/Bbs4Gt1Nk
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Mohg1C57BL/6J/Mohg1CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Mohg2C57BL/6J/Mohg2CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Mohg3C57BL/6J/Mohg3C57BL/6J,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Mohg3C57BL/6J/Mohg3CAST/EiJ,Socs2hg/Socs2hg
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004348 long femur "increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0004350 long humerus "increased length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004695 increased length of long bones "greater end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008162 increased diameter of tibia "increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008831 abnormal insulin-like growth factor I level "aomaly in the concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MESH:D12.644.276.937.400, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0008951 long radius "increased length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0009143 abnormal pancreatic duct morphology "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0009302 increased renal fat pad weight 
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009517 abnormal salivary gland duct morphology "any structural anomaly of the tubular canals that carry saliva" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Wehi/Socs2tm1Wehi
Genetic Background: C57BL/6-Socs2tm1Wehi

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arhgap33tm1.1Wbm/Arhgap33tm1.1Wbm,Cdc42tm1Brak/Cdc42+,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010967 increased compact bone area "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013631 decreased bone trabecular spacing "decrease in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Socs2tm1Vem/Socs2tm1Vem
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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