ENSMUSG00000038751


Mus musculus

Features
Gene ID: ENSMUSG00000038751
  
Biological name :Ptk6
  
Synonyms : Ptk6 / PTK6 protein tyrosine kinase 6 / Q64434
  
Possible biological names infered from orthology : protein tyrosine kinase 6 / Q13882
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 181193721
Gene end: 181202789
  
Corresponding Affymetrix probe sets: 10490611 (MoGene1.0st)   1442923_at (Mouse Genome 430 2.0 Array)   1450271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016511
NCBI entrez gene - 20459     See in Manteia.
MGI - MGI:99683
RefSeq - XM_017316742
RefSeq - NM_009184
RefSeq - XM_006500585
RefSeq Peptide - NP_033210
swissprot - Q64434
swissprot - Q05AA8
Ensembl - ENSMUSG00000038751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk6aENSDARG00000017947Danio rerio
 ptk6bENSDARG00000059956Danio rerio
 PTK6ENSG00000101213Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSMUSG0000002757946
Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*ENSMUSG0000001977945
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328341
Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*ENSMUSG0000001493241
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984341
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764641
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445340
Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*ENSMUSG0000002887440
Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000040939
Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*ENSMUSG0000004222838


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035846  PTK6, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045926 negative regulation of growth IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0060575 intestinal epithelial cell differentiation IMP
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Cyclin D associated events in G1
ERBB2 Activates PTK6 Signaling
PTK6 Regulates Proteins Involved in RNA Processing
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
PTK6 Regulates Cell Cycle
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
PTK6 Down-Regulation
PTK6 Activates STAT3
PTK6 promotes HIF1A stabilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptch2tm1Hui/Ptch2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000026058 Q9WU01 / Khdrbs2 / KH domain-containing, RNA-binding, signal transduction-associated protein 2 / Q5VWX1* / KH RNA binding domain containing, signal transduction associated 2*  / reaction
 ENSMUSG00000022332 Q9R226 / Khdrbs3 / KH domain-containing, RNA-binding, signal transduction-associated protein 3 / O75525* / KH RNA binding domain containing, signal transduction associated 3*  / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000028820 Sfpq / Q8VIJ6 / Splicing factor, proline- and glutamine-rich / P23246*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000029816 Gpnmb / Q99P91 / Transmembrane glycoprotein NMB / Q14956* / glycoprotein nmb*  / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex / reaction
 ENSMUSG00000036273 Lrrk2 / Q5S006 / Leucine-rich repeat serine/threonine-protein kinase 2 / Q5S007* / leucine rich repeat kinase 2*  / complex
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex / reaction
 ENSMUSG00000068335 Dok1 / P97465 / Docking protein 1 / Q99704*  / complex / reaction
 ENSMUSG00000058230 Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*  / complex / reaction
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000032812 Arap1 / Q4LDD4 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 / Q96P48* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / complex / reaction
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction
 ENSMUSG00000027579 Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*  / reaction
 ENSMUSG00000038781 Stap2 / Q8R0L1 / Signal-transducing adaptor protein 2 / Q9UGK3* / signal transducing adaptor family member 2*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / complex / reaction
 ENSMUSG00000028790 Q60749 / Khdrbs1 / KH domain-containing, RNA-binding, signal transduction-associated protein 1 / Q07666* / KH RNA binding domain containing, signal transduction associated 1*  / complex / reaction






 

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