ENSMUSG00000029377


Mus musculus

Features
Gene ID: ENSMUSG00000029377
  
Biological name :Ereg
  
Synonyms : Ereg / Proepiregulin Epiregulin / Q61521
  
Possible biological names infered from orthology : epiregulin / O14944
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 91074622
Gene end: 91093646
  
Corresponding Affymetrix probe sets: 10523175 (MoGene1.0st)   1419431_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031324
NCBI entrez gene - 13874     See in Manteia.
MGI - MGI:107508
RefSeq - NM_007950
RefSeq Peptide - NP_031976
swissprot - Q61521
Ensembl - ENSMUSG00000029377
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EREGENSGALG00000010864Gallus gallus
 EREGENSG00000124882Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001550 ovarian cumulus expansion IEA
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0007143 female meiotic nuclear division IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0009299 mRNA transcription IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030728 ovulation IEA
 biological_processGO:0042108 positive regulation of cytokine biosynthetic process IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042700 luteinizing hormone signaling pathway IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity ISS
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048160 primary follicle stage IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051151 negative regulation of smooth muscle cell differentiation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IDA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Aipl1tm1Visu/Aipl1tm1Visu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrp1tm2Ddg/Nrp1tm2.1Ddg,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / complex / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSMUSG00000024456 1 / Diaph1 / O08808 / O60610* / diaphanous related formin 1*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000028771 P35831 / Ptpn12 / protein tyrosine phosphatase, non-receptor type 12 / Q05209*  / reaction
 ENSMUSG00000058704 Memo1 / Q91VH6 / Protein MEMO1 / Q9Y316* / mediator of cell motility 1*  / complex / reaction
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / complex / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / complex / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / complex / reaction






 

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