ENSMUSG00000019471


Mus musculus

Features
Gene ID: ENSMUSG00000019471
  
Biological name :Cdc37
  
Synonyms : Cdc37 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q61081
  
Possible biological names infered from orthology : cell division cycle 37 / Q16543
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21133222
Gene end: 21149982
  
Corresponding Affymetrix probe sets: 10591472 (MoGene1.0st)   1416819_at (Mouse Genome 430 2.0 Array)   1416820_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150265
Ensembl peptide - ENSMUSP00000019615
NCBI entrez gene - 12539     See in Manteia.
MGI - MGI:109531
RefSeq - NM_016742
RefSeq - XM_006509967
RefSeq Peptide - NP_058022
swissprot - A0A1L1STC0
swissprot - Q61081
Ensembl - ENSMUSG00000019471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDC37ENSDARG00000099301Danio rerio
 CDC37ENSG00000105401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9CZP7 / Cdc37l1 / Hsp90 co-chaperone Cdc37-like 1 / Q7L3B6* / cell division cycle 37 like 1*ENSMUSG0000002478033


Protein motifs (from Interpro)
Interpro ID Name
 IPR004918  Cdc37
 IPR013855  Cdc37, N-terminal domain
 IPR013873  Cdc37, C-terminal
 IPR013874  Cdc37, Hsp90 binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IBA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0045859 regulation of protein kinase activity IDA
 biological_processGO:0050821 protein stabilization IBA
 biological_processGO:0060334 regulation of interferon-gamma-mediated signaling pathway ISO
 biological_processGO:0060338 regulation of type I interferon-mediated signaling pathway ISO
 biological_processGO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:1990565 HSP90-CDC37 chaperone complex IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019887 protein kinase regulator activity IDA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0051082 unfolded protein binding IBA
 molecular_functionGO:0051087 chaperone binding IBA
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction
 ENSMUSG00000019471 Cdc37 / Q61081 / Hsp90 co-chaperone Cdc37 Hsp90 co-chaperone Cdc37, N-terminally processed / Q16543* / cell division cycle 37*  / complex / reaction
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction
 ENSMUSG00000018166 Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*  / reaction
 ENSMUSG00000060275 Nrg2 / neuregulin 2 / O14511*  / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000021709 Erbin / Q80TH2 / Q96RT1* / erbb2 interacting protein*  / complex / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / complex / reaction






 

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