ENSMUSG00000021640


Mus musculus

Features
Gene ID: ENSMUSG00000021640
  
Biological name :Naip1
  
Synonyms : Naip1 / NLR family, apoptosis inhibitory protein 1 / Q9QWK5
  
Possible biological names infered from orthology : NAIP / NLR family apoptosis inhibitory protein / Q13075
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 100407764
Gene end: 100452869
  
Corresponding Affymetrix probe sets: 10411633 (MoGene1.0st)   1425298_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152120
Ensembl peptide - ENSMUSP00000152583
Ensembl peptide - ENSMUSP00000152253
Ensembl peptide - ENSMUSP00000022142
NCBI entrez gene - 17940     See in Manteia.
MGI - MGI:1298223
RefSeq - NM_008670
RefSeq Peptide - NP_032696
swissprot - A0A1Y7VLC9
swissprot - A0A1Y7VJ19
swissprot - Q9QWK5
Ensembl - ENSMUSG00000021640
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NAIPENSG00000249437Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Naip5 / NLR family, apoptosis inhibitory protein 5 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007120387
Naip6 / Q9JIB6 / NLR family, apoptosis inhibitory protein 6 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894286
Naip2 / Q9QUK4 / NLR family, apoptosis inhibitory protein 2 / NAIP* / Q13075* / NLR family apoptosis inhibitory protein*ENSMUSG0000007894585
Nlrc4 / Q3UP24 / NLR family CARD domain-containing protein 4 / Q9NPP4* / NLR family CARD domain containing 4*ENSMUSG0000003919316
Birc3 / baculoviral IAP repeat containing 3 / Q13489*ENSMUSG0000003200010
Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*ENSMUSG0000005736710
Xiap / Q60989 / X-linked inhibitor of apoptosis / BIRC8* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*ENSMUSG000000258608
Birc7 / A2AWP0 / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit / Q96CA5* / baculoviral IAP repeat containing 7*ENSMUSG000000388405


Protein motifs (from Interpro)
Interpro ID Name
 IPR001370  BIR repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028789  Baculoviral IAP repeat-containing protein 1
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0071391 cellular response to estrogen stimulus IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IBA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkgtm1Mka/Ikbkg+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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