ENSMUSG00000031497


Mus musculus

Features
Gene ID: ENSMUSG00000031497
  
Biological name :Tnfsf13b
  
Synonyms : Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b
  
Possible biological names infered from orthology : Q9Y275 / TNF superfamily member 13b
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 10006467
Gene end: 10039072
  
Corresponding Affymetrix probe sets: 10570018 (MoGene1.0st)   1445251_at (Mouse Genome 430 2.0 Array)   1458047_at (Mouse Genome 430 2.0 Array)   1460255_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033892
Ensembl peptide - ENSMUSP00000146694
Ensembl peptide - ENSMUSP00000146904
NCBI entrez gene - 24099     See in Manteia.
MGI - MGI:1344376
RefSeq - XM_006508775
RefSeq - NM_033622
RefSeq - XM_006508774
RefSeq Peptide - NP_001334238
RefSeq Peptide - NP_296371
swissprot - Q3KP92
swissprot - Q8BVA3
swissprot - Q9WU72
Ensembl - ENSMUSG00000031497
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf13bENSDARG00000012945Danio rerio
 ENSGALG00000045364Gallus gallus
 TNFSF13BENSGALG00000016852Gallus gallus
 Q9Y275ENSG00000102524Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnfsfm13 / tumor necrosis factor (ligand) superfamily, membrane-bound member 13 / TNFSF12-TNFSF13* / TNFSF12-TNFSF13 readthrough*ENSMUSG0000001875222
Tnfsf13 / tumor necrosis factor (ligand) superfamily, member 13 / O75888* / TNF superfamily member 13*ENSMUSG0000008966920
O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...ENSMUSG0000009732811


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002636 positive regulation of germinal center formation IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030890 positive regulation of B cell proliferation ISO
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0031296 B cell costimulation IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0048305 immunoglobulin secretion IGI
 biological_processGO:0050776 regulation of immune response IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13b+
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bm2Btlr/Tnfsf13bm2Btlr
Genetic Background: C57BL/6J-Tnfsf13bm2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13b+
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Tnfsf13bm1Anu/Tnfsf13bm1Anu
Genetic Background: C57BL/6JAnu-Tnfsf13bm1Anu/Apb

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Unc13atm2Bros/Unc13atm2Bros
Genetic Background: involves: FVB/N

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Unc13atm2Bros/Unc13atm2Bros
Genetic Background: involves: FVB/N

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129S2/SvPas

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13b+
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13b+
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bm2Btlr/Tnfsf13bm2Btlr
Genetic Background: C57BL/6J-Tnfsf13bm2Btlr

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129S2/SvPas

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13b+
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

 MP:0008175 absent follicular B cells "absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Lck-cre)I57Jxm/?,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: C57BL/6 * ICR * SJL

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Slc11a1r/Slc11a1r
Genetic Background: C3H/HeJ

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129S2/SvPas

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Tnfsf13bm1Anu/Tnfsf13bm1Anu
Genetic Background: C57BL/6JAnu-Tnfsf13bm1Anu/Apb

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf13bm1Anu/Tnfsf13bm1Anu
Genetic Background: C57BL/6JAnu-Tnfsf13bm1Anu/Apb

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Tnfsf13btm1Cleg/Tnfsf13btm1Cleg
Genetic Background: involves: 129S5/SvEvBrd

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13bM1Btlr
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bM1Btlr/Tnfsf13b+
Genetic Background: C57BL/6J-Tnfsf13bM1Btlr

Allelic Composition: Tnfsf13bm2Btlr/Tnfsf13bm2Btlr
Genetic Background: C57BL/6J-Tnfsf13bm2Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010142 Q9ET35 / Tnfrsf13b / tumor necrosis factor receptor superfamily, member 13b / O14836* / TNF receptor superfamily member 13B*  / complex / reaction
 ENSMUSG00000022496 O88472 / Tnfrsf17 / Tumor necrosis factor receptor superfamily member 17 / Q02223* / TNF receptor superfamily member 17*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000068105 Q9D8D0 / Tnfrsf13c / tumor necrosis factor receptor superfamily, member 13c / Q96RJ3* / TNF receptor superfamily member 13C*  / complex / reaction






 

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