ENSMUSG00000010142


Mus musculus

Features
Gene ID: ENSMUSG00000010142
  
Biological name :Tnfrsf13b
  
Synonyms : Q9ET35 / Tnfrsf13b / tumor necrosis factor receptor superfamily, member 13b
  
Possible biological names infered from orthology : O14836 / TNF receptor superfamily member 13B
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 61126755
Gene end: 61149372
  
Corresponding Affymetrix probe sets: 10376755 (MoGene1.0st)   1423182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010286
Ensembl peptide - ENSMUSP00000116943
Ensembl peptide - ENSMUSP00000116175
Ensembl peptide - ENSMUSP00000098662
NCBI entrez gene - 57916     See in Manteia.
MGI - MGI:1889411
RefSeq - XM_006533852
RefSeq - NM_021349
RefSeq - XM_006533851
RefSeq Peptide - NP_067324
swissprot - B1ATI4
swissprot - Q9ET35
swissprot - A5D8Y6
swissprot - B1ATI3
Ensembl - ENSMUSG00000010142
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFRSF13BENSGALG00000024122Gallus gallus
 O14836ENSG00000240505Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015384  TACI, cysteine-rich domain
 IPR022317  Tumour necrosis factor receptor 13B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxo1tm1Flv/Foxo1tm1Flv,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002345 abnormal lymph node primary follicle "anomaly in the immunologically inactive B cell area of the lymph node cortex" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2btm1Rsp/Grin2btm1Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Tg(Tnfsf13b)1Fma/?,Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: B6.Cg-Tnfrsf13btm1Rjb Tg(Tnfsf13b)1Fma

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm2Crm/Sox9tm2Crm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0011506 glomerular crescent "formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Tnfrsf13btm1Vmd/Tnfrsf13btm1Vmd
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010142 Q9ET35 / Tnfrsf13b / tumor necrosis factor receptor superfamily, member 13b / O14836* / TNF receptor superfamily member 13B*  / complex / reaction
 ENSMUSG00000089669 Tnfsf13 / tumor necrosis factor (ligand) superfamily, member 13 / O75888* / TNF superfamily member 13*  / complex / reaction
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / complex / reaction
 ENSMUSG00000022496 O88472 / Tnfrsf17 / Tumor necrosis factor receptor superfamily member 17 / Q02223* / TNF receptor superfamily member 17*  / complex / reaction






 

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