ENSMUSG00000089669


Mus musculus
increasedTnfsf13secretioninterleukin-decreasednecrosistumourfactoriggdomainregulationreceptoractivityigamembranebindingtcellspleengerminalcenterlevelfactor-likesuperfamilyconservedsiteimmuneresponsesignalingisotypeswitching

Features
Gene ID: ENSMUSG00000089669
  
Biological name :Tnfsf13
  
Synonyms : Tnfsf13 / tumor necrosis factor (ligand) superfamily, member 13
  
Possible biological names infered from orthology : O75888 / TNF superfamily member 13
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69682846
Gene end: 69685784
  
Corresponding Affymetrix probe sets: 1418345_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018896
Ensembl peptide - ENSMUSP00000104288
NCBI entrez gene - 69583     See in Manteia.
MGI - MGI:1916833
RefSeq - NM_023517
RefSeq - NM_001159505
RefSeq Peptide - NP_001152977
RefSeq Peptide - NP_076006
swissprot - Q5F2A3
swissprot - Q5F2A4
Ensembl - ENSMUSG00000089669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf13ENSDARG00000091556Danio rerio
 O75888ENSG00000161955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnfsfm13 / tumor necrosis factor (ligand) superfamily, membrane-bound member 13 / TNFSF12-TNFSF13* / TNFSF12-TNFSF13 readthrough*ENSMUSG0000001875258
Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*ENSMUSG0000003149726
O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...ENSMUSG0000009732815


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
immune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune responsecell communicationregulation of molecular functioncellular response to stimulusnitrogen compound metabolic processproduction of molecular mediator of immune responsecellular metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentcell activationimmune effector processimmune respimmune responsecell communcell communicationregulation regulation of molecular functioncellular recellular response to stimulusnitrogen conitrogen compound metabolic processproduction production of molecular mediator of immune responsecellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processanatomical anatomical structure developmentcell activacell activationimmune effeimmune effector process
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regioncellmembraneextracellular regionextracellular regioncellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0048298 positive regulation of isotype switching to IgA isotypes IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
HuR (ELAVL1) binds and stabilizes mRNA
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
immune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypehematopoietic system phenotypeskeleton phenotypeimmune system phenotypeimmune system phenotypehematopoietic system phenotypehematopoietic system phenotypeskeleton phenotypeskeleton phenotype
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13+
Genetic Background: B6.Cg-Tnfsf13tm1Pod

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Ptch1tm1Zim/Ptch1+
Genetic Background: involves: 129/Sv * CD-1

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Tnfsf13tm1Pod/Tnfsf13tm1Pod
Genetic Background: B6.Cg-Tnfsf13tm1Pod

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010142 Q9ET35 / Tnfrsf13b / tumor necrosis factor receptor superfamily, member 13b / O14836* / TNF receptor superfamily member 13B*  / complex / reaction
 ENSMUSG00000089669 Tnfsf13 / tumor necrosis factor (ligand) superfamily, member 13 / O75888* / TNF superfamily member 13*  / complex
 ENSMUSG00000022496 O88472 / Tnfrsf17 / Tumor necrosis factor receptor superfamily member 17 / Q02223* / TNF receptor superfamily member 17*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr