ENSDARG00000044619


Danio rerio

Features
Gene ID: ENSDARG00000044619
  
Biological name :birc2
  
Synonyms : baculoviral IAP repeat containing 2 / birc2
  
Possible biological names infered from orthology : baculoviral IAP repeat containing 3 / Baculoviral IAP repeat-containing protein 2 / BIRC3 / Q13489 / Q13490 / Q62210
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 22833905
Gene end: 22851230
  
Corresponding Affymetrix probe sets: Dr.2849.1.S1_at (Zebrafish Array)   NM_194395_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000151933
Ensembl peptide - ENSDARP00000065554
Ensembl peptide - ENSDARP00000103254
Ensembl peptide - ENSDARP00000126110
NCBI entrez gene - 373107     See in Manteia.
RefSeq - NM_194395
RefSeq - XM_005161156
RefSeq - XM_017352755
RefSeq Peptide - NP_919376
swissprot - Q7T0K2
swissprot - A0A0R4I9H2
ZFIN ID - ZDB-GENE-030825-6
Ensembl - ENSDARG00000044619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BIRC2ENSGALG00000017186Gallus gallus
 BIRC2ENSG00000110330Homo sapiens
 BIRC3ENSG00000023445Homo sapiens
 Birc2ENSMUSG00000057367Mus musculus
 Birc3ENSMUSG00000032000Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
xiap / X-linked inhibitor of apoptosis / BIRC8* / Q60989* / P98170* / Q96P09* / baculoviral IAP repeat containing 8*ENSDARG0000001614324
birc7 / baculoviral IAP repeat containing 7 / A2AWP0* / Q96CA5* / Baculoviral IAP repeat-containing protein 7 Baculoviral IAP repeat-containing protein 7 30 kDa subunit*ENSDARG0000005808223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type
 IPR011029  Death-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
NOD1/2 Signaling Pathway
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood mislocalised , abnormal
Show

 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta blood vessel endothelial cell apoptotic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein blood vessel endothelial cell apoptotic , abnormal
Show

 ZFA:0001079 blood vasculature blood vasculature degenerate , abnormal
Show

 ZFA:0001114 head head color , abnormal
head necrotic , abnormal
Show

 ZFA:0001115 trunk trunk degenerate , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel decreased diameter , abnormal
intersegmental vessel blood circulation absent , abnormal
Show

 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell apoptotic , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell apoptotic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000012945 tnfsf13b / TNF superfamily member 13b / Q9Y275*  / complex
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / complex / reaction
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex / reaction
 ENSDARG00000068141 tnfsf11 / TNF superfamily member 11 / O14788* / O35235* / tumor necrosis factor (ligand) superfamily, member 11*  / complex / reaction
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSDARG00000087804 tnfrsf11a / tumor necrosis factor receptor superfamily, member 11a, NFKB activator / CD40* / Q9Y6Q6* / O35305* / P25942* / P27512* / CD40 molecule* / TNF receptor superfamily member 11a* / ...  / complex / reaction
 ENSDARG00000054968 cd40 / CD40 molecule, TNF receptor superfamily member 5 / P27512* / O35305* / P25942* / Q9Y6Q6* / TNFRSF11A* / CD40 molecule* / TNF receptor superfamily member 11a* / Tumor necrosis factor ...  / complex / reaction
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex / reaction
 ENSDARG00000004132 usp19 / ubiquitin specific peptidase 19 / O94966* / Q3UJD6*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr