ENSDARG00000013598


Danio rerio
necrosissignalingtnfrtnfbtumourfactordomainliverregulationreceptoractivitymembrane-inducedpathwayalphalymphotoxin-alphafactor-likesuperfamilydevelopmentimmuneresponseextracellularspaceintegralcomponentcytokinetumorbindingproapoptoticnfkappab-mediated

Features
Gene ID: ENSDARG00000013598
  
Biological name :tnfb
  
Synonyms : tnfb / tumor necrosis factor b (TNF superfamily, member 2)
  
Possible biological names infered from orthology : LTA / lymphotoxin A / lymphotoxin alpha / P01374 / P01375 / P06804 / P09225 / TNF / tumor necrosis factor
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 34699585
Gene end: 34702661
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000010728
NCBI entrez gene - 554167     See in Manteia.
RefSeq - NM_001024447
RefSeq Peptide - NP_001019618
swissprot - Q4W898
ZFIN ID - ZDB-GENE-050601-2
Ensembl - ENSDARG00000013598
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LTAENSG00000226979Homo sapiens
 TNFENSG00000232810Homo sapiens
 LtaENSMUSG00000024402Mus musculus
 TnfENSMUSG00000024401Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnfa / tumor necrosis factor a (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*ENSDARG0000000951136
faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*ENSDARG0000009891316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002959  Tumour necrosis factor alpha
 IPR002960  Lymphotoxin-alpha
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
anatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developmentimmune responsecell communicationregulation of molecular functioncellular response to stimulusanatomical structure developanatomical structure developmentimmune responseimmune responsecell communicationcell communicationregulation of molecular funcregulation of molecular functioncellular response to stimulucellular response to stimulus
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionextracellular regionmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / complex / reaction
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000022000 traf3 / TNF receptor-associated factor 3 / Q13114* / Q60803*  / complex / reaction
 ENSDARG00000043179 bag4 / BCL2 associated athanogene 4 / O95429* / Q8CI61* / BAG family molecular chaperone regulator 4 *  / reaction
 ENSDARG00000040523 smpd2a / sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase) / SMPD2* / O60906* / sphingomyelin phosphodiesterase 2*  / complex / reaction
 ENSDARG00000051920 nsmaf / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / complex / reaction
 ENSDARG00000052701 smpd2b / sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase) / SMPD2* / O70572* / O60906* / sphingomyelin phosphodiesterase 2* / sphingomyelin phosphodiesterase ...  / complex / reaction
 ENSDARG00000041619 rack1 / O42248 / receptor for activated C kinase 1 / P68040* / P63244* / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed*  / complex / reaction
 ENSDARG00000070165 tnfrsf1b / tumor necrosis factor receptor superfamily, member 1B / P20333* / P25119* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / complex / reaction
 ENSDARG00000098226 smpd3 / sphingomyelin phosphodiesterase 3, neutral / Q9JJY3* / Q9NY59* / sphingomyelin phosphodiesterase 3*  / complex / reaction
 ENSDARG00000044619 birc2 / baculoviral IAP repeat containing 2 / BIRC3* / Q13489* / Q13490* / Q62210* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction






 

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