ENSDARG00000051920


Danio rerio

Features
Gene ID: ENSDARG00000051920
  
Biological name :nsmaf
  
Synonyms : neutral sphingomyelinase (N-SMase) activation associated factor / nsmaf
  
Possible biological names infered from orthology : neutral sphingomyelinase activation associated factor / O35242 / Q92636
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 58139372
Gene end: 58178980
  
Corresponding Affymetrix probe sets: Dr.21229.1.A1_s_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068125
Ensembl peptide - ENSDARP00000156816
NCBI entrez gene - 550506     See in Manteia.
swissprot - F1QZ06
ZFIN ID - ZDB-GENE-050417-342
Ensembl - ENSDARG00000051920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NSMAFENSGALG00000038838Gallus gallus
 NSMAFENSG00000035681Homo sapiens
 NsmafENSMUSG00000028245Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nbeal2 / neurobeachin-like 2 / Q6ZNJ1* / Q6ZQA0* / Neurobeachin-like protein 2 *ENSDARG0000009864127
lrba / LPS-responsive vesicle trafficking, beach and anchor containing / P50851* / LPS responsive beige-like anchor protein*ENSDARG0000003110826
nbeaa / neurobeachin a / NBEA* / Q9EPN1* / Q8NFP9* / neurobeachin*ENSDARG0000007008026
nbeal1 / neurobeachin-like 1 / Q6ZS30*ENSDARG0000009954726
nbeab / neurobeachin b / NBEA* / Q9EPN1* / Q8NFP9* / neurobeachin*ENSDARG0000010518426
wdfy3 / WD repeat and FYVE domain containing 3 / Q6VNB8* / Q8IZQ1*ENSDARG0000007889025
lyst / lysosomal trafficking regulator / Q99698*ENSDARG0000000857524
wdfy4 / WDFY family member 4 / Q6ZS81* / WD repeat and FYVE domain containing 4*ENSDARG0000007700921
wdr81 / E7FEV0 / WD repeat domain 81 / Q562E7* / Q5ND34*ENSDARG0000007970210


Protein motifs (from Interpro)
Interpro ID Name
 IPR000409  BEACH domain
 IPR001680  WD40 repeat
 IPR004182  GRAM domain
 IPR011993  PH-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR023362  PH-BEACH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002232 leukocyte chemotaxis involved in inflammatory response IMP
 biological_processGO:0002233 leukocyte chemotaxis involved in immune response IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP


Pathways (from Reactome)
Pathway description
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009309 leukocyte leukocyte morphology , abnormal
leukocyte cellular motility , abnormal
leukocyte pseudopodium increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018569 tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / P25118* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSDARG00000013598 tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*  / complex / reaction
 ENSDARG00000040523 smpd2a / sphingomyelin phosphodiesterase 2a, neutral membrane (neutral sphingomyelinase) / SMPD2* / O60906* / sphingomyelin phosphodiesterase 2*  / complex / reaction
 ENSDARG00000052701 smpd2b / sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase) / SMPD2* / O70572* / O60906* / sphingomyelin phosphodiesterase 2* / sphingomyelin phosphodiesterase ...  / complex / reaction
 ENSDARG00000041619 rack1 / O42248 / receptor for activated C kinase 1 / P68040* / P63244* / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed*  / complex / reaction
 ENSDARG00000098226 smpd3 / sphingomyelin phosphodiesterase 3, neutral / Q9JJY3* / Q9NY59* / sphingomyelin phosphodiesterase 3*  / complex / reaction






 

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