ENSDARG00000098913


Danio rerio

Features
Gene ID: ENSDARG00000098913
  
Biological name :faslg
  
Synonyms : faslg / Fas ligand (TNF superfamily, member 6)
  
Possible biological names infered from orthology : Fasl / Fas ligand / P41047 / P48023 / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble form ADAM10-processed FasL form FasL intracellular domain
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 15600167
Gene end: 15605010
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000136343
NCBI entrez gene - 735295     See in Manteia.
swissprot - Q0PKX7
ZFIN ID - ZDB-GENE-070410-16
Ensembl - ENSDARG00000098913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FASLGENSGALG00000003076Gallus gallus
 FASLGENSG00000117560Homo sapiens
 FaslENSMUSG00000000817Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnfa / tumor necrosis factor a (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*ENSDARG0000000951114
tnfb / tumor necrosis factor b (TNF superfamily, member 2) / LTA* / TNF* / P01375* / P06804* / P09225* / P01374* / lymphotoxin A* / lymphotoxin alpha* / tumor necrosis factor*ENSDARG0000001359814


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0030903 notochord development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFs bind their physiological receptors
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000135 notochord notochord bent , abnormal
notochord morphology , abnormal
notochord increased thickness , abnormal
notochord undulate , abnormal
notochord basement membrane increased thickness , abnormal
notochord basement membrane undulate , abnormal
notochord vacuole increased size , abnormal
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 ZFA:0001094 whole organism whole organism decreased mobility , abnormal
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 ZFA:0001114 head head edematous , abnormal
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 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
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 ZFA:0001189 vertebra vertebra morphology , abnormal
vertebra fused with vertebra , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell orientation skeletal muscle cell , abnormal
skeletal muscle cell disorganized , abnormal
skeletal muscle cell undulate , abnormal
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 ZFA:0009244 primary motor neuron primary motor neuron axon increased branchiness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / complex / reaction
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000070272 casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / complex / reaction






 

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