ENSDARG00000043586


Danio rerio

Features
Gene ID: ENSDARG00000043586
  
Biological name :fas
  
Synonyms : fas / Fas cell surface death receptor
  
Possible biological names infered from orthology : P25445 / P25446 / Tumor necrosis factor receptor superfamily member 6
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 23619924
Gene end: 23631411
  
Corresponding Affymetrix probe sets: DrAffx.2.77.A1_at (Zebrafish Array)   DrAffx.2.77.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074016
NCBI entrez gene - 768248     See in Manteia.
swissprot - F1QG24
ZFIN ID - ZDB-GENE-061019-2
Ensembl - ENSDARG00000043586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FASENSGALG00000006351Gallus gallus
 FASENSG00000026103Homo sapiens
 FasENSMUSG00000024778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR008063  Fas receptor
 IPR011029  Death-like domain superfamily
 IPR033998  Fas receptor, death domain
 IPR034055  Tumor necrosis factor receptor 6, N-terminal, teleost


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000135 notochord notochord bent , abnormal
Show

 ZFA:0001114 head head edematous , abnormal
Show

 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / complex / reaction
 ENSDARG00000070272 casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*  / complex / reaction
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr