ENSDARG00000043586


Danio rerio

Features
Gene ID: ENSDARG00000043586
  
Biological name :fas
  
Synonyms : fas / Fas cell surface death receptor
  
Possible biological names infered from orthology : P25445 / P25446 / Tumor necrosis factor receptor superfamily member 6
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 23619924
Gene end: 23631411
  
Corresponding Affymetrix probe sets: DrAffx.2.77.A1_at (Zebrafish Array)   DrAffx.2.77.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074016
NCBI entrez gene - 768248     See in Manteia.
swissprot - F1QG24
ZFIN ID - ZDB-GENE-061019-2
Ensembl - ENSDARG00000043586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FASENSGALG00000006351Gallus gallus
 FASENSG00000026103Homo sapiens
 FasENSMUSG00000024778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR008063  Fas receptor
 IPR011029  Death-like domain superfamily
 IPR033998  Fas receptor, death domain
 IPR034055  Tumor necrosis factor receptor 6, N-terminal, teleost


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000135 notochord notochord bent , abnormal
Show

 ZFA:0001114 head head edematous , abnormal
Show

 ZFA:0001117 post-vent region post-vent region increased curvature , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / complex / reaction
 ENSDARG00000070272 casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*  / complex / reaction
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / complex / reaction






 

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