ENSDARG00000055966


Danio rerio
domaincflaraactivitypeptidaseregulationcysteine-typecdeathsuperfamilyapoptoticexecutionphaseapoptosissignalingendopeptidasepeffectordeath-likecaspasecatalyticcaspase-likeproteolysisprocessextrinsicpathwayviareceptorscytoplasminvolvedc-flipripk

Features
Gene ID: ENSDARG00000055966
  
Biological name :cflara
  
Synonyms : CASP8 and FADD-like apoptosis regulator a / cflara
  
Possible biological names infered from orthology : CASP8 and FADD like apoptosis regulator / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / CFLAR / O15519 / O35732
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 30332959
Gene end: 30341431
  
Corresponding Affymetrix probe sets: DrAffx.1.48.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072840
NCBI entrez gene - 373114     See in Manteia.
RefSeq - NM_001313772
RefSeq Peptide - NP_001300701
swissprot - F1R706
ZFIN ID - ZDB-GENE-030826-3
Ensembl - ENSDARG00000055966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CFLARENSGALG00000008240Gallus gallus
 CFLARENSG00000003402Homo sapiens
 CflarENSMUSG00000026031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cflarb / CASP8 and FADD-like apoptosis regulator b / CFLAR* / O15519* / CASP8 and FADD like apoptosis regulator*ENSDARG0000007480216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001309  Peptidase C14, p20 domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR015917  Peptidase C14A, caspase catalytic domain
 IPR029030  Caspase-like domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell deathcell communicationcellular response to stimulusnitrogen compound metabnitrogen compound metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processcell deathcell deathcell communicationcell communicationcellular response to stcellular response to stimulus
catalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteinhydrolase activitycatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activity
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0097194 execution phase of apoptosis IBA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004392 hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...  / complex / reaction
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / complex / reaction
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000057241 tnfsf10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / complex / reaction






 

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