ENSDARG00000057241


Danio rerio

Features
Gene ID: ENSDARG00000057241
  
Biological name :tnfsf10
  
Synonyms : tnfsf10 / TNF superfamily member 10
  
Possible biological names infered from orthology : P50591 / P50592 / tumor necrosis factor (ligand) superfamily, member 10
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 26932472
Gene end: 26937526
  
Corresponding Affymetrix probe sets: DrAffx.2.78.A1_at (Zebrafish Array)   DrAffx.2.78.S1_at (Zebrafish Array)   NM_001002593_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000074299
Ensembl peptide - ENSDARP00000148431
NCBI entrez gene - 436866     See in Manteia.
RefSeq - NM_001328527
RefSeq - NM_001002593
RefSeq Peptide - NP_001002593
RefSeq Peptide - NP_001315456
swissprot - Q6DHG9
ZFIN ID - ZDB-GENE-040718-335
Ensembl - ENSDARG00000057241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNFSF10ENSGALG00000009179Gallus gallus
 P50591ENSG00000121858Homo sapiens
 P50592ENSMUSG00000039304Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnfsf10l / TNF superfamily member 10, likeENSDARG0000000419628
tnfsf10l3 / tumor necrosis factor (ligand) superfamily, member 10 like 3ENSDARG0000003274626
tnfsf10l4 / tumor necrosis factor (ligand) superfamily, member 10 like 4ENSDARG0000005806818
tnfsf11 / TNF superfamily member 11 / O14788* / O35235* / tumor necrosis factor (ligand) superfamily, member 11*ENSDARG0000006814118


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR017355  Tumour necrosis factor ligand 10/11
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Dimerization of procaspase-8
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / complex / reaction
 ENSDARG00000004392 hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...  / complex / reaction
 ENSDARG00000070272 casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*  / complex / reaction
 ENSDARG00000057241 tnfsf10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction






 

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