ENSDARG00000103021


Danio rerio

Features
Gene ID: ENSDARG00000103021
  
Biological name :fadd
  
Synonyms : fadd / Fas (tnfrsf6)-associated via death domain
  
Possible biological names infered from orthology : FAS-associated death domain protein / Fas associated via death domain / Q13158 / Q61160
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 54313489
Gene end: 54320088
  
Corresponding Affymetrix probe sets: DrAffx.2.52.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000140007
NCBI entrez gene - 562317     See in Manteia.
swissprot - A0A0R4IXF0
ZFIN ID - ZDB-GENE-070606-3
Ensembl - ENSDARG00000103021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FADDENSGALG00000007625Gallus gallus
 FADDENSG00000168040Homo sapiens
 FaddENSMUSG00000031077Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004392 hdr / hematopoietic death receptor / Q9QZM4* / Q9UBN6* / O00220* / O14763* / O14798* / TNFRSF10D* / TNFRSF10C* / TNFRSF10B* / TNFRSF10A* / TNF receptor superfamily member 10a* / TNF recepto...  / complex / reaction
 ENSDARG00000036057 tradd / Q9I9N5 / tnfrsf1a-associated via death domain / Q15628* / Q3U0V2*  / complex / reaction
 ENSDARG00000019742 tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex / reaction
 ENSDARG00000022048 tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000055966 cflara / CASP8 and FADD-like apoptosis regulator a / CFLAR* / O35732* / O15519* / CASP8 and FADD like apoptosis regulator* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apop...  / complex / reaction
 ENSDARG00000043586 fas / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction
 ENSDARG00000057241 tnfsf10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / complex / reaction
 ENSDARG00000075671 tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*  / complex
 ENSDARG00000070272 casp8l2 / caspase 8, apoptosis-related cysteine peptidase, like 2 / CASP10* / Q92851* / caspase 10*  / complex / reaction
 ENSDARG00000103021 fadd / Fas (tnfrsf6)-associated via death domain / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSDARG00000098913 faslg / Fas ligand (TNF superfamily, member 6) / P48023* / Fas ligand*  / complex / reaction
 ENSDARG00000102493 ticam1 / toll-like receptor adaptor molecule 1 / Q8BJQ4* / Q8IUC6* / Q80UF7* / TICAM2* / Q86XR7* / toll like receptor adaptor molecule 2* / TIR domain-containing adapter molecule 2 * / TIR ...  / complex






 

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