ENSGALG00000006351


Gallus gallus

Features
Gene ID: ENSGALG00000006351
  
Biological name :FAS
  
Synonyms : FAS / Fas cell surface death receptor
  
Possible biological names infered from orthology : P25445 / P25446 / Tumor necrosis factor receptor superfamily member 6
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 19256327
Gene end: 19268640
  
Corresponding Affymetrix probe sets: Gga.100.1.S1_a_at (Chicken Array)   Gga.10683.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000039128
NCBI entrez gene - 395274     See in Manteia.
RefSeq - XM_015288355
RefSeq - NM_001199487
RefSeq - XM_015288353
RefSeq - XM_015288354
RefSeq - XM_015288351
RefSeq - XM_015288352
RefSeq Peptide - NP_001186416
swissprot - F1P2Q5
Ensembl - ENSGALG00000006351
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fasENSDARG00000043586Danio rerio
 FASENSG00000026103Homo sapiens
 FasENSMUSG00000024778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR008063  Fas receptor
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032872 regulation of stress-activated MAPK cascade IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0036337 Fas signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071455 cellular response to hyperoxia IEA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0031265 CD95 death-inducing signaling complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043120 tumor necrosis factor binding IBA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
CASP8 activity is inhibited
Dimerization of procaspase-8
FasL/ CD95L signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008240 CFLAR / CASP8 and FADD-like apoptosis regulator / O15519* / O35732* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apopto...  / complex / reaction
 ENSGALG00000007625 FADD / Fas associated via death domain / Q13158* / Q61160* / FAS-associated death domain protein *  / complex / reaction
 ENSGALG00000003076 FASLG / Fas ligand / Fasl* / P41047* / P48023* / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor lig...  / complex / reaction
 ENSGALG00000006351 FAS / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / complex / reaction






 

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