ENSG00000076604


Homo sapiens

Features
Gene ID: ENSG00000076604
  
Biological name :TRAF4
  
Synonyms : Q9BUZ4 / TNF receptor associated factor 4 / TRAF4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 28743984
Gene end: 28750958
  
Corresponding Affymetrix probe sets: 202871_at (Human Genome U133 Plus 2.0 Array)   211899_s_at (Human Genome U133 Plus 2.0 Array)   235688_s_at (Human Genome U133 Plus 2.0 Array)   242473_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465164
Ensembl peptide - ENSP00000464583
Ensembl peptide - ENSP00000466306
Ensembl peptide - ENSP00000481248
Ensembl peptide - ENSP00000468107
Ensembl peptide - ENSP00000262395
Ensembl peptide - ENSP00000262396
Ensembl peptide - ENSP00000396602
Ensembl peptide - ENSP00000415789
Ensembl peptide - ENSP00000438154
Ensembl peptide - ENSP00000464097
NCBI entrez gene - 9618     See in Manteia.
OMIM - 602464
RefSeq - XM_011525508
RefSeq - NM_004295
RefSeq - XM_011525504
RefSeq - XM_011525505
RefSeq - XM_011525506
RefSeq - XM_011525507
RefSeq Peptide - NP_004286
swissprot - K7EJG7
swissprot - K7EM06
swissprot - K7ER49
swissprot - A0A024QZ59
swissprot - Q2KJU6
swissprot - Q9BUZ4
swissprot - C9JJ10
swissprot - A0A0C4DFM9
swissprot - F6SA91
swissprot - J3QR87
swissprot - J9JIG0
swissprot - J3QS94
Ensembl - ENSG00000076604
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf4aENSDARG00000003963Danio rerio
 TRAF4ENSGALG00000003987Gallus gallus
 Traf4ENSMUSG00000017386Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF5 / O00463 / TNF receptor associated factor 5ENSG0000008251229
TRAF2 / Q12933 / TNF receptor associated factor 2ENSG0000012719129
TRAF3 / Q13114 / TNF receptor associated factor 3ENSG0000013132328
TRAF6 / Q9Y4K3 / TNF receptor associated factor 6ENSG0000017510424
TRAF1 / Q13077 / TNF receptor associated factor 1ENSG0000005655820


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027138  TNF receptor-associated factor 4
 IPR037307  TNF receptor-associated factor 4, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0030323 respiratory tube development IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050699 WW domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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