ENSG00000175104


Homo sapiens

Features
Gene ID: ENSG00000175104
  
Biological name :TRAF6
  
Synonyms : Q9Y4K3 / TNF receptor associated factor 6 / TRAF6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p12
Gene start: 36487027
Gene end: 36510272
  
Corresponding Affymetrix probe sets: 205558_at (Human Genome U133 Plus 2.0 Array)   227264_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000337853
Ensembl peptide - ENSP00000433623
NCBI entrez gene - 7189     See in Manteia.
OMIM - 602355
RefSeq - NM_004620
RefSeq - NM_145803
RefSeq Peptide - NP_004611
RefSeq Peptide - NP_665802
swissprot - Q9Y4K3
Ensembl - ENSG00000175104
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf6ENSDARG00000028058Danio rerio
 TRAF6ENSGALG00000007932Gallus gallus
 Traf6ENSMUSG00000027164Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF5 / O00463 / TNF receptor associated factor 5ENSG0000008251225
TRAF2 / Q12933 / TNF receptor associated factor 2ENSG0000012719125
TRAF3 / Q13114 / TNF receptor associated factor 3ENSG0000013132324
TRAF4 / Q9BUZ4 / TNF receptor associated factor 4ENSG0000007660421
TRAF1 / Q13077 / TNF receptor associated factor 1ENSG0000005655816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027139  TNF receptor-associated factor 6
 IPR037309  TNF receptor-associated factor 6, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002726 positive regulation of T cell cytokine production IMP
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IMP
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination NAS
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042088 T-helper 1 type immune response IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0043507 positive regulation of JUN kinase activity NAS
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II NAS
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051865 protein autoubiquitination TAS
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070534 protein K63-linked ubiquitination IGI
 biological_processGO:0070555 response to interleukin-1 IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035631 CD40 receptor complex ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IPI
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0043422 protein kinase B binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
MyD88:Mal cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Regulated proteolysis of p75NTR
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000457 Flat nose 
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 HP:0000668 Hypodontia "Hypodontia describes a situation when there are fewer than the normal number of teeth, whereby 6 teeth or fewer teeth are missing (oligodontia refers to the condition of missing more than 6 teeth and the congenital absence of all teeth is called anodontia)." [HPO:curators]
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 HP:0000963 Thin skin 
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 HP:0000964 Eczema "Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." [HPO:curators]
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 HP:0000966 Hypohidrosis "Abnormally diminished capacity to sweat." [HPO:curators]
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 HP:0001000 Abnormality of skin pigmentation 
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 HP:0001006 Hypotrichosis "Reduced or lacking hair growth." [HPO:curators]
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 HP:0001231 Abnormality of the fingernails "An abnormality of the `fingernails` (FMA:54327)." [HPO:probinson]
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 HP:0002047 Malignant hyperthermia "Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine." [HPO:curators]
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 HP:0002231 Sparse body hair "Sparseness of the body hair." [HPO:probinson]
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 HP:0006323 Premature deciduous tooth loss 
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 HP:0006482 Abnormality of dental morphology 
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 HP:0011220 Prominent forehead "Forward prominence of the entire forehead, due to protrusion of the frontal bone." [pmid:19125436]
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 HP:0012471 Thick vermilion border "Increased width of the "skin of vermilion border region of upper lip" (FMA:312645)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196083 IL1RAP / Q9NPH3 / interleukin 1 receptor accessory protein  / complex / reaction
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / complex / reaction
 ENSG00000101916 TLR8 / Q9NR97 / toll like receptor 8  / complex / reaction
 ENSG00000205155 PSENEN / Q9NZ42 / presenilin enhancer gamma-secretase subunit  / reaction
 ENSG00000117362 APH1A / Q96BI3 / aph-1 homolog A, gamma-secretase subunit  / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / complex / reaction
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / complex / reaction
 ENSG00000125538 IL1B / P01584 / interleukin 1 beta  / complex / reaction
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000078902 Q9H0E2 / TOLLIP / toll interacting protein  / complex / reaction
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000138613 APH1B / Q8WW43 / aph-1 homolog B, gamma-secretase subunit  / reaction
 ENSG00000114316 USP4 / Q13107 / ubiquitin specific peptidase 4  / reaction / complex
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex / reaction
 ENSG00000115008 IL1A / P01583 / interleukin 1 alpha  / complex / reaction
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / complex / reaction
 ENSG00000174123 TLR10 / Q9BXR5 / toll like receptor 10  / complex / reaction
 ENSG00000139946 PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000135218 CD36 / P16671 / CD36 molecule  / complex / reaction
 ENSG00000174125 TLR1 / Q15399 / toll like receptor 1  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000163558 PRKCI / P41743 / protein kinase C iota  / complex / reaction
 ENSG00000162736 NCSTN / Q92542 / nicastrin  / reaction
 ENSG00000083799 CYLD / Q9NQC7 / CYLD lysine 63 deubiquitinase  / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / complex / reaction
 ENSG00000080815 PSEN1 / P49768 / presenilin 1  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000197329 PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1  / complex / reaction
 ENSG00000172175 MALT1 / Q9UDY8 / MALT1 paracaspase  / complex / reaction
 ENSG00000198286 CARD11 / Q9BXL7 / caspase recruitment domain family member 11  / complex / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / reaction
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / complex / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000115602 IL1RL1 / Q01638 / interleukin 1 receptor like 1  / complex
 ENSG00000118503 P21580 / TNFAIP3 / TNF alpha induced protein 3  / complex
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000142856 Q13352 / ITGB3BP / integrin subunit beta 3 binding protein  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / complex / reaction
 ENSG00000019995 Q9UGI0 / ZRANB1 / zinc finger RANBP2-type containing 1  / complex
 ENSG00000198909 MAP3K3 / Q99759 / mitogen-activated protein kinase kinase kinase 3  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / - / complex / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000187796 CARD9 / Q9H257 / caspase recruitment domain family member 9  / complex / reaction
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000142867 BCL10 / O95999 / B cell CLL/lymphoma 10  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / complex / reaction
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000174130 TLR6 / Q9Y2C9 / toll like receptor 6  / complex / reaction
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / complex / reaction
 ENSG00000137033 IL33 / O95760 / interleukin 33  / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / complex / reaction
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000264522 OTUD7B / Q6GQQ9 / OTU deubiquitinase 7B  / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex
 ENSG00000187554 TLR5 / O60602 / toll like receptor 5  / complex / reaction
 ENSG00000143801 PSEN2 / P49810 / presenilin 2  / reaction
 ENSG00000095015 MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1  / complex / reaction
 ENSG00000115594 IL1R1 / P14778 / interleukin 1 receptor type 1  / complex / reaction






 

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