ENSGALG00000007932


Gallus gallus

Features
Gene ID: ENSGALG00000007932
  
Biological name :TRAF6
  
Synonyms : TNF receptor associated factor 6 / TRAF6
  
Possible biological names infered from orthology : P70196 / Q9Y4K3
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 19483884
Gene end: 19564179
  
Corresponding Affymetrix probe sets: GgaAffx.4973.1.S1_at (Chicken Array)   GgaAffx.4973.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012873
NCBI entrez gene - 423163     See in Manteia.
RefSeq - XM_004941546
RefSeq - XM_004941547
RefSeq - XM_004941548
RefSeq - XM_015287208
RefSeq - XM_004941545
swissprot - E1C626
Ensembl - ENSGALG00000007932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf6ENSDARG00000028058Danio rerio
 TRAF6ENSG00000175104Homo sapiens
 Traf6ENSMUSG00000027164Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF2 / TNF receptor associated factor 2 / P39429* / Q12933*ENSGALG0000004283825
TRAF5 / TNF receptor associated factor 5 / O00463*ENSGALG0000000986424
TRAF1 / TNF receptor associated factor 1 / P39428* / Q13077*ENSGALG0000000158321
TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*ENSGALG0000001138921
TRAF4 / TNF receptor associated factor 4 / Q61382* / Q9BUZ4*ENSGALG0000000398719


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR027139  TNF receptor-associated factor 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway NAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0042088 T-helper 1 type immune response IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0048468 cell development IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035631 CD40 receptor complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043422 protein kinase B binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
TRAF mediated activation of IRF
TRAF6 mediated NF-kB activation
MyD88:Mal cascade initiated on plasma membrane
Regulated proteolysis of p75NTR
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
NFkB and MAPK activation mediated by TRAF6
TRAF6 mediated induction of proinflammatory cytokines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
NFkB activation mediated by RIP1 complexed with activated TLR3
Activated TAK1 mediates p38 MAP kinase phosphorylation
Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
Ovarian tumor domain proteases
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation
Interleukin-1 signaling
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex / reaction
 ENSGALG00000004398 CARD11 / caspase recruitment domain family member 11 / Q8CIS0* / Q9BXL7* / Caspase recruitment domain-containing protein 11 *  / complex / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / complex / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / - / complex / reaction
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / complex / reaction
 ENSGALG00000007253 IL1RAP / interleukin 1 receptor accessory protein / Q61730* / Q9NPH3*  / complex / reaction
 ENSGALG00000014718 MAP3K1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*  / complex / reaction
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / complex / reaction
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000016590 TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*  / complex / reaction
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / complex / reaction
 ENSGALG00000009364 PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*  / complex / reaction
 ENSGALG00000009586 IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*  / complex / reaction
 ENSGALG00000003753 CYLD / CYLD lysine 63 deubiquitinase / Q80TQ2* / Q9NQC7* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / complex / reaction
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSGALG00000034970 PRKCQ / protein kinase C theta / Q02111* / Q04759*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex / reaction
 ENSGALG00000040224 TIRAP / TIR domain containing adaptor protein / P58753* / toll-interleukin 1 receptor (TIR) domain-containing adaptor protein*  / complex / reaction
 ENSGALG00000030063 MALT1 / MALT1 paracaspase / Q2TBA3* / Q9UDY8* / Mucosa-associated lymphoid tissue lymphoma translocation *  / complex / reaction
 ENSGALG00000029940 IL1B / interleukin 1 beta / P01584* / P10749*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000043044 IL1R1 / interleukin-1 receptor type 1 precursor / P14778* / P13504* / interleukin 1 receptor type 1* / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleuki...  / complex / reaction
 ENSGALG00000030526 IL1R1* / P13504* / P14778* / interleukin 1 receptor type 1* / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form*  / complex / reaction
 ENSGALG00000013348 OTUD7B / OTU deubiquitinase 7B / B2RUR8* / Q6GQQ9* / OTU domain-containing protein 7B *  / complex
 ENSGALG00000013861 TNFAIP3 / TNF alpha induced protein 3 / P21580* / Q60769* / tumor necrosis factor, alpha-induced protein 3*  / complex
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSGALG00000031474 ZRANB1 / zinc finger RANBP2-type containing 1 / Q7M760* / Q9UGI0* / zinc finger, RAN-binding domain containing 1*  / complex
 ENSGALG00000000525 MAP3K3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*  / complex / reaction
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex / reaction
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction






 

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