ENSGALG00000002556


Gallus gallus

Features
Gene ID: ENSGALG00000002556
  
Biological name :NGF
  
Synonyms : nerve growth factor / NGF
  
Possible biological names infered from orthology : Beta-nerve growth factor / P01138 / P01139
  
Species: Gallus gallus
  
Chr. number: 26
Strand: -1
Band:
Gene start: 4027896
Gene end: 4047968
  
Corresponding Affymetrix probe sets: Gga.5163.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000047700
Ensembl peptide - ENSGALP00000004030
NCBI entrez gene - 396466     See in Manteia.
RefSeq - XM_015298897
RefSeq - NM_001293108
RefSeq - NM_001293109
RefSeq Peptide - NP_001280037
RefSeq Peptide - NP_001280038
swissprot - A0A140T8F7
Ensembl - ENSGALG00000002556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngfaENSDARG00000058961Danio rerio
 ngfbENSDARG00000014050Danio rerio
 NGFENSG00000134259Homo sapiens
 NgfENSMUSG00000027859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NTF3 / neurotrophin 3 / P20181* / P20783*ENSGALG0000002729938
BDNF / P25429 / Brain-derived neurotrophic factor / P21237* / P23560*ENSGALG0000001216336


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR020425  Nerve growth factor, beta subunit
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0048812 neuron projection morphogenesis IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005163 nerve growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
NGF processing
Frs2-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
TRKA activation by NGF
PI3K/AKT activation
NFG and proNGF binds to p75NTR
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000009364 PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*  / complex / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / reaction / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex / reaction
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000008443 ARHGDIA / rho GDP-dissociation inhibitor 1 / P52565* / Q99PT1* / Rho GDP dissociation inhibitor alpha*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000006390 CRKL / CRK like proto-oncogene, adaptor protein / P46109* / P47941* / Crk-like protein *  / complex
 ENSGALG00000008341 FURIN / furin, paired basic amino acid cleaving enzyme / P09958* / P23188*  / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSGALG00000043451 DNAL4 / dynein axonemal light chain 4 / O96015* / Q9DCM4* / Dynein light chain 4, axonemal *  / reaction
 ENSGALG00000033256 PCSK5* / Q04592* / Q92824* / proprotein convertase subtilisin/kexin type 5*  / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr