ENSGALG00000027299


Gallus gallus
regulationNTF3activityreceptorgrowthsignalingnerveactivationphosphorylationntrkfactorproteinkinasecellpeptidyl-tyrosinechemotaxismembranebindingactivatedsignalsfactor-relatedneurotrophin-conservedsitefactor-likecystine-knotcytokinemapkinternalizationtransmembranetyrosine

Features
Gene ID: ENSGALG00000027299
  
Biological name :NTF3
  
Synonyms : neurotrophin 3 / NTF3
  
Possible biological names infered from orthology : P20181 / P20783
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 73984538
Gene end: 74054787
  
Corresponding Affymetrix probe sets: GgaAffx.11073.1.S1_at (Chicken Array)   GgaAffx.20691.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043385
NCBI entrez gene - 428099     See in Manteia.
RefSeq - NM_001109762
RefSeq Peptide - NP_001103232
swissprot - R4GMC6
Ensembl - ENSGALG00000027299
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntf3ENSDARG00000059043Danio rerio
 NTF3ENSG00000185652Homo sapiens
 Ntf3ENSMUSG00000049107Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BDNF / P25429 / Brain-derived neurotrophic factor / P21237* / P23560*ENSGALG0000001216335
NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *ENSGALG0000000255634


Protein motifs (from Interpro)
Interpro ID Name
 IPR002072  Nerve growth factor-related
 IPR015578  Neurotrophin-3
 IPR019846  Nerve growth factor conserved site
 IPR020408  Nerve growth factor-like
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscellular component organizationestablishment of localizationlocalization of cellmovement of cell or subcellular componentcell deathresponse to external stimulusresponse to chemicalactin filament-based processnitrogen nitrogen compound metabolic processcell commcell communicationcellular cellular metabolic processprimary mprimary metabolic processregulatioregulation of molecular functionorganic sorganic substance metabolic processcellular cellular response to stimuluscellular cellular component organizationestablishestablishment of localizationlocalizatlocalization of cellmovement movement of cell or subcellular componentcell deatcell deathresponse response to external stimulusresponse response to chemicalactin filactin filament-based process
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
membranemembranemembranemembranemembranemembranemembranemembranemembranemembranemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005165 neurotrophin receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042056 chemoattractant activity IEA


Pathways (from Reactome)
Pathway description
NTF3 activates NTRK3 signaling
Activated NTRK3 signals through PLCG1
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000027299 NTF3 / neurotrophin 3 / P20181* / P20783*  / complex
 ENSGALG00000040241 NTRK3 / Q91044 / NT-3 growth factor receptor / Q16288* / Q6VNS1* / neurotrophic receptor tyrosine kinase 3*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr