ENSGALG00000015096


Gallus gallus

Features
Gene ID: ENSGALG00000015096
  
Biological name :SH3GL2
  
Synonyms : Endophilin-A1 / Q8AXV1 / SH3GL2
  
Possible biological names infered from orthology : Q62420 / Q99962 / SH3 domain containing GRB2 like 2, endophilin A1 / SH3-domain GRB2-like 2
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 32972022
Gene end: 33061468
  
Corresponding Affymetrix probe sets: Gga.25.1.S1_at (Chicken Array)   Gga.25.1.S2_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000024312
NCBI entrez gene - 395203     See in Manteia.
RefSeq - NM_204530
RefSeq Peptide - NP_989861
swissprot - Q8AXV1
Ensembl - ENSGALG00000015096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SH3GL2 (1 of many)ENSDARG00000039901Danio rerio
 sh3gl2aENSDARG00000023600Danio rerio
 Q99962ENSG00000107295Homo sapiens
 Q62420ENSMUSG00000028488Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8AXV0 / SH3GL1 / Endophilin-A2 / Q99961* / Q62419* / SH3-domain GRB2-like 1* / SH3 domain containing GRB2 like 1, endophilin A2*ENSGALG0000000112175
SH3GL3 / endophilin-A3 / Q99963* / endophilin-A3 isoform 3 * / SH3 domain containing GRB2 like 3, endophilin A3*ENSGALG0000000604570
Q5ZIR1 / SH3GLB1 / Endophilin-B1 / Q9JK48* / Q9Y371* / SH3 domain containing GRB2 like, endophilin B1*ENSGALG0000000628425
Q5ZJ81 / SH3GLB2 / Endophilin-B2 / Q9NR46* / Q8R3V5* / SH3-domain GRB2-like endophilin B2* / SH3 domain containing GRB2 like, endophilin B2*ENSGALG0000003954124


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR004148  BAR domain
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002090 regulation of receptor internalization IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0016191 synaptic vesicle uncoating IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 biological_processGO:0097484 dendrite extension IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
EGFR downregulation
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Recycling pathway of L1
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004594 CD74 / CD74 molecule / P04233* / P04441* / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)*  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex / reaction
 ENSGALG00000007224 HGS / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex / reaction
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex / reaction
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / complex
 ENSGALG00000010543 EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSGALG00000001501 MAPK1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSGALG00000019019 NTRK1 / high affinity nerve growth factor receptor precursor / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000035287 STAM / signal transducing adaptor molecule / P70297* / Q92783* / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1*  / complex / reaction
 ENSGALG00000043451 DNAL4 / dynein axonemal light chain 4 / O96015* / Q9DCM4* / Dynein light chain 4, axonemal *  / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction






 

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