ENSGALG00000010543


Gallus gallus

Features
Gene ID: ENSGALG00000010543
  
Biological name :EPS15
  
Synonyms : epidermal growth factor receptor substrate 15 / EPS15
  
Possible biological names infered from orthology : epidermal growth factor receptor pathway substrate 15 / P42566 / P42567
  
Species: Gallus gallus
  
Chr. number: 8
Strand: -1
Band:
Gene start: 24138119
Gene end: 24180613
  
Corresponding Affymetrix probe sets: Gga.20080.1.S1_at (Chicken Array)   Gga.4092.1.S1_at (Chicken Array)   Gga.4092.2.S1_at (Chicken Array)   Gga.4092.2.S1_x_at (Chicken Array)   GgaAffx.11399.1.S1_at (Chicken Array)   GgaAffx.11399.1.S1_s_at (Chicken Array)   GgaAffx.6665.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046919
Ensembl peptide - ENSGALP00000053354
Ensembl peptide - ENSGALP00000017141
NCBI entrez gene - 424633     See in Manteia.
RefSeq - XM_015291018
RefSeq - XM_015291014
RefSeq - XM_015291015
RefSeq - XM_015291016
RefSeq - XM_015291017
RefSeq - NM_001031283
RefSeq - XM_015291013
RefSeq Peptide - NP_001026454
swissprot - A0A1D5PKJ5
swissprot - F1NLF0
swissprot - A0A1D5P2M3
Ensembl - ENSGALG00000010543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eps15ENSDARG00000078216Danio rerio
 EPS15ENSG00000085832Homo sapiens
 Eps15ENSMUSG00000028552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPS15L1 / epidermal growth factor receptor pathway substrate 15 like 1 / Q60902* / Q9UBC2* / Epidermal growth factor receptor substrate 15-like 1 *ENSGALG0000002160149
ITSN2 / intersectin 2 / Q9NZM3*ENSGALG0000001650421
ITSN1 / intersectin 1 / Q15811* / Q9Z0R4*ENSGALG0000003667721
REPS1 / ralBP1-associated Eps domain-containing protein 1 / O54916* / Q96D71* / RALBP1 associated Eps domain containing 1*ENSGALG0000001382915
REPS2 / ralBP1-associated Eps domain-containing protein 2 / Q8NFH8* / RALBP1 associated Eps domain containing 2*ENSGALG0000001654513
EHD4 / EH domain containing 4 / Q9EQP2* / Q9H223* / EH domain-containing protein 4 *ENSGALG0000000895010
EHD3 / EH domain-containing protein 3 / Q9NZN3* / Q9QXY6* / EH domain containing 3*ENSGALG0000000908610
SRL / sarcalumenin precursor / Q7TQ48* / Q86TD4* / sarcalumenin*ENSGALG000000388846


Protein motifs (from Interpro)
Interpro ID Name
 IPR000261  EH domain
 IPR002048  EF-hand domain
 IPR003903  Ubiquitin interacting motif
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006895 Golgi to endosome transport IEA
 biological_processGO:0019065 receptor-mediated endocytosis of virus by host cell IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048268 clathrin coat assembly IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000007224 HGS / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex
 ENSGALG00000012585 Q8R317* / Q9QZM0* / Q9UHD9* / Q9UMX0* / UBQLN2* / UBQLN1* / ubiquilin 1* / ubiquilin 2*  / complex / reaction
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / complex / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000035287 STAM / signal transducing adaptor molecule / P70297* / Q92783* / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1*  / complex
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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