ENSGALG00000038089


Gallus gallus

Features
Gene ID: ENSGALG00000038089
  
Biological name :EGFR
  
Synonyms : EGFR / epidermal growth factor receptor
  
Possible biological names infered from orthology : P00533 / Q01279
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 51987050
Gene end: 52134485
  
Corresponding Affymetrix probe sets: Gga.2304.1.S1_at (Chicken Array)   Gga.857.1.S1_at (Chicken Array)   Gga.857.2.S1_s_at (Chicken Array)   GgaAffx.23879.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045732
Ensembl peptide - ENSGALP00000053328
NCBI entrez gene - 396494     See in Manteia.
RefSeq - XM_015281330
RefSeq - NM_205497
RefSeq - XM_015281328
RefSeq - XM_015281329
RefSeq Peptide - NP_990828
swissprot - A0A1D5PKH0
swissprot - A0A1D5NZB4
Ensembl - ENSGALG00000038089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EGFRENSG00000146648Homo sapiens
 EgfrENSMUSG00000020122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*ENSGALG0000000312653
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152951
ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSGALG0000003351042
PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*ENSGALG0000001656415
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174115
SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*ENSGALG0000001521613
TNK2 / tyrosine kinase non receptor 2 / Q07912*ENSGALG0000002798313
ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...ENSGALG0000000148612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000494  Receptor L-domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR006211  Furin-like cysteine-rich domain
 IPR006212  Furin-like repeat
 IPR008266  Tyrosine-protein kinase, active site
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR016245  Tyrosine protein kinase, EGF/ERB/XmrK receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR032778  Growth factor receptor domain 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010750 positive regulation of nitric oxide mediated signal transduction IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070141 response to UV-A IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900020 positive regulation of protein kinase C activity IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1905208 negative regulation of cardiocyte differentiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097489 multivesicular body, internal vesicle lumen IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005006 epidermal growth factor-activated receptor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030235 nitric-oxide synthase regulator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
EGFR Transactivation by Gastrin
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000949 HBEGF / Q9W7C5 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186* / Q99075* / heparin binding EGF like growth factor*  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000002952 NRG4 / neuregulin 4 / Q8WWG1* / Q9WTX4* / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / complex / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / complex
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / complex / reaction
 ENSGALG00000016906 SPRY2 / protein sprouty homolog 2 / O43597* / Q9QXV8* / sprouty RTK signaling antagonist 2*  / reaction / complex
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000028608 BTC / probetacellulin precursor / P35070* / Q05928* / betacellulin* / Probetacellulin Betacellulin*  / complex / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000000736 MATK / megakaryocyte-associated tyrosine kinase / P42679*  / complex / reaction
 ENSGALG00000007161 LRRK2 / leucine-rich repeat serine/threonine-protein kinase 2 / Q5S006* / Q5S007* / leucine rich repeat kinase 2*  / complex
 ENSGALG00000010949 GPNMB / glycoprotein nmb / Q14956* / Q99P91* / Transmembrane glycoprotein NMB *  / complex / reaction
 ENSGALG00000010543 EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000010624 MEMO1 / mediator of cell motility 1 / Q91VH6* / Q9Y316* / Protein MEMO1 *  / complex / reaction
 ENSGALG00000035919 EPN2 / epsin-2 / O95208* / Q8CHU3*  / complex / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000042067 SPRY1 / sprouty RTK signaling antagonist 1 / O43609* / Q9QXV9*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction
 ENSGALG00000042569 P35831* / PTPN12* / Q05209* / protein tyrosine phosphatase, non-receptor type 12*  / reaction






 

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