ENSGALG00000027983


Gallus gallus

Features
Gene ID: ENSGALG00000027983
  
Biological name :TNK2
  
Synonyms : TNK2 / tyrosine kinase non receptor 2
  
Possible biological names infered from orthology : Q07912
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 15004028
Gene end: 15017912
  
Corresponding Affymetrix probe sets: Gga.6309.1.S1_at (Chicken Array)   GgaAffx.11362.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054783
Ensembl peptide - ENSGALP00000042503
NCBI entrez gene - 431014     See in Manteia.
RefSeq - XM_015291461
RefSeq - XM_015291459
RefSeq - XM_015291460
RefSeq - XM_004943345
RefSeq - XM_015291455
RefSeq - XM_015291456
RefSeq - XM_015291457
RefSeq - XM_015291458
swissprot - R4GK19
swissprot - A0A1D5PPI3
Ensembl - ENSGALG00000027983
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnk2aENSDARG00000090646Danio rerio
 tnk2bENSDARG00000104409Danio rerio
 TNK2ENSG00000061938Homo sapiens
 Tnk2ENSMUSG00000022791Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*ENSGALG0000000312615
PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*ENSGALG0000001656414
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152914
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174114
ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSGALG0000003351014
EGFR / epidermal growth factor receptor / P00533* / Q01279*ENSGALG0000003808914
SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*ENSGALG0000001521611
ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...ENSGALG0000000148610


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR015116  Cdc42 binding domain-like
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR021619  Mig-6 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0070436 Grb2-EGFR complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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