ENSGALG00000016564


Gallus gallus

Features
Gene ID: ENSGALG00000016564
  
Biological name :PTK2B
  
Synonyms : protein tyrosine kinase 2 beta / PTK2B
  
Possible biological names infered from orthology : PTK2 protein tyrosine kinase 2 beta / Q14289 / Q9QVP9
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 105498872
Gene end: 105511445
  
Corresponding Affymetrix probe sets: Gga.1082.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026682
Ensembl peptide - ENSGALP00000052015
NCBI entrez gene - 421998     See in Manteia.
RefSeq - XM_015285226
RefSeq - XM_015285224
RefSeq - XM_015285225
RefSeq - XM_003641070
RefSeq - XM_004935841
RefSeq - XM_015285220
RefSeq - XM_015285221
RefSeq - XM_015285222
RefSeq - XM_015285223
swissprot - E1BTC3
swissprot - A0A1D5PGU1
Ensembl - ENSGALG00000016564
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptk2baENSDARG00000022841Danio rerio
 ptk2bbENSDARG00000039577Danio rerio
 PTK2BENSG00000120899Homo sapiens
 Ptk2bENSMUSG00000059456Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174145
ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*ENSGALG0000000312620
EGFR / epidermal growth factor receptor / P00533* / Q01279*ENSGALG0000003808918
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152917
ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSGALG0000003351016
TNK2 / tyrosine kinase non receptor 2 / Q07912*ENSGALG0000002798315
ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...ENSGALG0000000148613
SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*ENSGALG0000001521613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000299  FERM domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR005189  Focal adhesion kinase, targeting (FAT) domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR030610  Protein-tyrosine kinase 2-beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0002315 marginal zone B cell differentiation IEA
 biological_processGO:0002688 regulation of leukocyte chemotaxis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007010 cytoskeleton organization IBA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007172 signal complex assembly IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010752 regulation of cGMP-mediated signaling IEA
 biological_processGO:0010758 regulation of macrophage chemotaxis IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0030502 negative regulation of bone mineralization IEA
 biological_processGO:0030826 obsolete regulation of cGMP biosynthetic process IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0032960 regulation of inositol trisphosphate biosynthetic process IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042976 activation of Janus kinase activity IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043267 negative regulation of potassium ion transport IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045428 regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050848 regulation of calcium-mediated signaling IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization IEA
 biological_processGO:2000538 positive regulation of B cell chemotaxis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA


Pathways (from Reactome)
Pathway description
VEGFA-VEGFR2 Pathway
Interleukin-2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / complex / reaction
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / complex / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / reaction
 ENSGALG00000033234 JAK3 / tyrosine-protein kinase JAK3 / P52333* / Janus kinase 3*  / complex / reaction






 

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