ENSGALG00000001486


Gallus gallus

Features
Gene ID: ENSGALG00000001486
  
Biological name :ZAP70
  
Synonyms : Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / ZAP70
  
Possible biological names infered from orthology : P43403 / P43404 / zeta chain of T cell receptor associated protein kinase 70 / zeta-chain (TCR) associated protein kinase
  
Species: Gallus gallus
  
Chr. number: 28
Strand: 1
Band:
Gene start: 1808132
Gene end: 1829433
  
Corresponding Affymetrix probe sets: GgaAffx.968.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002252
NCBI entrez gene - 420086     See in Manteia.
RefSeq - NM_001321556
RefSeq - XM_418206
RefSeq Peptide - NP_001308485
swissprot - E1BU42
Ensembl - ENSGALG00000001486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zap70ENSDARG00000015752Danio rerio
 ZAP70ENSG00000115085Homo sapiens
 Zap70ENSMUSG00000026117Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*ENSGALG0000001521658
ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*ENSGALG0000000312625
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152924
ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSGALG0000003351024
EGFR / epidermal growth factor receptor / P00533* / Q01279*ENSGALG0000003808924
PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*ENSGALG0000001656422
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174122
TNK2 / tyrosine kinase non receptor 2 / Q07912*ENSGALG0000002798319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012234  Tyrosine-protein kinase, non-receptor SYK/ZAP-70
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR023420  Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043366 beta selection IEA
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045060 negative thymic T cell selection IEA
 biological_processGO:0045061 thymic T cell selection IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0042101 T cell receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / reaction
 ENSGALG00000004958 BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / reaction






 

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