ENSMUSG00000026117


Mus musculus

Features
Gene ID: ENSMUSG00000026117
  
Biological name :Zap70
  
Synonyms : P43404 / Zap70 / zeta-chain (TCR) associated protein kinase
  
Possible biological names infered from orthology : P43403 / zeta chain of T cell receptor associated protein kinase 70
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 36761798
Gene end: 36782818
  
Corresponding Affymetrix probe sets: 10345509 (MoGene1.0st)   1422701_at (Mouse Genome 430 2.0 Array)   1439749_at (Mouse Genome 430 2.0 Array)   1440178_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027291
Ensembl peptide - ENSMUSP00000139990
NCBI entrez gene - 22637     See in Manteia.
MGI - MGI:99613
RefSeq - XM_006495896
RefSeq - NM_001289765
RefSeq - NM_001289766
RefSeq - NM_009539
RefSeq Peptide - NP_001276694
RefSeq Peptide - NP_001276695
RefSeq Peptide - NP_033565
swissprot - P43404
swissprot - A0A087WQ05
Ensembl - ENSMUSG00000026117
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zap70ENSDARG00000015752Danio rerio
 ZAP70ENSGALG00000001486Gallus gallus
 ZAP70ENSG00000115085Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*ENSMUSG0000002145755
Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*ENSMUSG0000006220925
Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*ENSMUSG0000006231224
Erbb3 / Q61526 / Receptor tyrosine-protein kinase erbB-3 / P21860* / erb-b2 receptor tyrosine kinase 3*ENSMUSG0000001816623
Egfr / Q01279 / Epidermal growth factor receptor / P00533*ENSMUSG0000002012223
Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*ENSMUSG0000002260723
Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*ENSMUSG0000005945622
Tnk2 / tyrosine kinase, non-receptor, 2 / Q07912*ENSMUSG0000002279121
Tnk1 / Q99ML2 / Non-receptor tyrosine-protein kinase TNK1 / Q13470* / tyrosine kinase non receptor 1*ENSMUSG0000000158320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012234  Tyrosine-protein kinase, non-receptor SYK/ZAP-70
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR023420  Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
 IPR035838  SYK/ZAP-70, N-terminal SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0043366 beta selection IGI
 biological_processGO:0045059 positive thymic T cell selection IEA
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0045061 thymic T cell selection IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IMP
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IGI
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0042101 T cell receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Pcdh15av-2J/Pcdh15av-2J
Genetic Background: B6C3Fe a/a-Pcdh15av-2J/J

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Pcdh15av-2J/Pcdh15av-2J
Genetic Background: B6C3Fe a/a-Pcdh15av-2J/J

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Tap1m2Btlr/Tap1m2Btlr
Genetic Background: C57BL/6J-Tap1m2Btlr

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gusbmps-3J/Gusbmps-3J
Genetic Background: C57BL/6J-Gusbmps-3J/J

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Zap70m3Btlr/Zap70m3Btlr
Genetic Background: C57BL/6J-Zap70m3Btlr

Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70st/Zap70tm1Dlo
Genetic Background: involves: C57BL/6

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slatm1Weis/Slatm1Weis,Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m6Hefl/Zap70m6Hefl
Genetic Background: C3HeB/FeJ-Zap70m6Hefl

Allelic Composition: Foxp3tm2Ayr/?,Zap70rps/Zap70rps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m1Saka/Zap70tm1Dlo,Tg(Lck-ZAP70)824Saka/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp3tm2Ayr/?,Zap70rps/Zap70rps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mrtle/Zap70rps
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxp3tm2Ayr/?,Zap70rps/Zap70rps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mrtle/Zap70rps
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70m6Hefl/Zap70m6Hefl
Genetic Background: C3HeB/FeJ-Zap70m6Hefl

Allelic Composition: Zap70m6Hefl/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0002935 chronic joint inflammation "persistant inflammatory response in the joints, often caused by persistant infection or during an autoimmune response" [RGD:Rat Genome Database submission]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m1Saka/Zap70m1Saka,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: BALB/c * C57BL/6J * DBA/2J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2

 MP:0003189 fused joints 
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Zap70m1Saka/Zap70tm2.1Weis
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0004917 abnormal T cell selection "any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation" [GO:0045058]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m1Saka/Zap70m1Saka,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: BALB/c * C57BL/6J * DBA/2J

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2J

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129S4/SvJae * BALB/c * C3H * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm2Ayr/?,Zap70rps/Zap70rps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mrtle/Zap70rps
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0005002 abnormal T cell clonal deletion "a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

Allelic Composition: Zap70m1Saka/Zap70tm2.1Weis
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctsgtm2.1(PML/RARA)Ley/Ctsg+,Elanetm1Sds/Elanetm1Sds
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

Allelic Composition: Zap70m1Saka/Zap70m1Saka,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

Allelic Composition: Zap70m6Hefl/Zap70m6Hefl
Genetic Background: C3HeB/FeJ-Zap70m6Hefl

Allelic Composition: Zap70m6Hefl/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C3HeB/FeJ * C57BL/10 * DBA/2

Allelic Composition: Zap70m1Btlr/Zap70m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Zap70m2Btlr/Zap70m2Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Zap70m4Btlr/Zap70m4Btlr
Genetic Background: C57BL/6J-Zap70m4Btlr

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nr3c1tm3Gsc/Nr3c1tm3Gsc
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Zap70mrtle/Zap70rps
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: involves: C57BL/6JSfdAnu

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m1Saka/Zap70m1Saka,Tg(DO11.10)10Dlo/0
Genetic Background: involves: BALB/c * C3H * C57BL/6

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: En1tm2(cre)Wrst/En1+,Gbx2tm1.1Mrt/Gbx2tm1.1Alj
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcrLCMV)327Sdz/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * DBA/2

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0008070 absent T cells "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: C57BL/6JSfdAnu-Zap70mrtle/Apb

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slatm1Weis/Slatm1Weis,Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m6Hefl/Zap70m6Hefl
Genetic Background: C3HeB/FeJ-Zap70m6Hefl

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: B6.129S4-Zap70tm2.1Weis

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

Allelic Composition: Foxp3tm2Ayr/?,Zap70rps/Zap70rps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mrtle/Zap70rps
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Zap70m4Btlr/Zap70m4Btlr
Genetic Background: C57BL/6J-Zap70m4Btlr

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70m6Hefl/Zap70m6Hefl
Genetic Background: C3HeB/FeJ-Zap70m6Hefl

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: B6.129S4-Zap70tm2.1Weis

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

Allelic Composition: Foxp3tm2Ayr/?,Zap70rps/Zap70rps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Zap70mrtle/Zap70rps
Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

Allelic Composition: Zap70mrtle/Zap70mrtle
Genetic Background: involves: C57BL/6JSfdAnu

Allelic Composition: Zap70m4Btlr/Zap70m4Btlr
Genetic Background: C57BL/6J-Zap70m4Btlr

Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: B6.129S4-Zap70tm2.1Weis

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Syktm1Kuro/Syktm1Kuro,Zap70tm1Dlo/Zap70tm1Dlo,Cd79atm1(cre)Reth/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70m6Hefl/Zap70m6Hefl
Genetic Background: C3HeB/FeJ-Zap70m6Hefl

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: B6.129S4-Zap70tm2.1Weis

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Zap70tm1Weis/Zap70tm1Weis
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Zap70m1Saka/Zap70m1Saka
Genetic Background: involves: BALB/c

Allelic Composition: Zap70tm2.1Mmal/Zap70tm2.1Mmal,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6J * DBA/2J

Allelic Composition: Zap70tm2.1Weis/Zap70tm2.1Weis
Genetic Background: C.129S4-Zap70tm2.1Weis

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

 MP:0010841 increased central memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
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Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
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Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

Allelic Composition: Zap70m7Btlr/Zap70m7Btlr
Genetic Background: C57BL/6J-Zap70m7Btlr

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
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Allelic Composition: Zap70m5Btlr/Zap70m5Btlr
Genetic Background: C57BL/6J-Zap70m5Btlr

Allelic Composition: Zap70m6Btlr/Zap70m6Btlr
Genetic Background: C57BL/6J-Zap70m6Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Zap70m3Btlr/Zap70m3Btlr
Genetic Background: C57BL/6J-Zap70m3Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / complex / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / reaction
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex / reaction
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / reaction






 

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