ENSGALG00000015216


Gallus gallus

Features
Gene ID: ENSGALG00000015216
  
Biological name :SYK
  
Synonyms : F1N9Y5 / SYK / Tyrosine-protein kinase SYK
  
Possible biological names infered from orthology : P43405 / P48025 / spleen associated tyrosine kinase / spleen tyrosine kinase
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 44064049
Gene end: 44115933
  
Corresponding Affymetrix probe sets: GgaAffx.12646.1.S1_at (Chicken Array)   GgaAffx.9684.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000032170
Ensembl peptide - ENSGALP00000024509
NCBI entrez gene - 427272     See in Manteia.
RefSeq - XM_015280298
RefSeq - NM_001031430
RefSeq - XM_015280297
RefSeq Peptide - NP_001026601
swissprot - F1N9Y5
swissprot - A0A0A0MQ53
Ensembl - ENSGALG00000015216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sykENSDARG00000008186Danio rerio
 SYKENSG00000165025Homo sapiens
 SykENSMUSG00000021457Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...ENSGALG0000000148655
ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*ENSGALG0000000312625
EGFR / epidermal growth factor receptor / P00533* / Q01279*ENSGALG0000003808925
ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *ENSGALG0000003152924
ERBB3 / receptor tyrosine-protein kinase erbB-3 precursor / P21860* / Q61526* / erb-b2 receptor tyrosine kinase 3* / Receptor tyrosine-protein kinase erbB-3 *ENSGALG0000003351024
PTK2B / protein tyrosine kinase 2 beta / Q14289* / Q9QVP9* / PTK2 protein tyrosine kinase 2 beta*ENSGALG0000001656421
PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*ENSGALG0000003174121
TNK2 / tyrosine kinase non receptor 2 / Q07912*ENSGALG0000002798319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR012234  Tyrosine-protein kinase, non-receptor SYK/ZAP-70
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR023420  Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001820 serotonin secretion IEA
 biological_processGO:0001945 lymph vessel development IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002281 macrophage activation involved in immune response IEA
 biological_processGO:0002283 neutrophil activation involved in immune response IEA
 biological_processGO:0002366 leukocyte activation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002554 serotonin secretion by platelet IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007257 activation of JUN kinase activity IEA
 biological_processGO:0010543 regulation of platelet activation IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0032928 regulation of superoxide anion generation IEA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0042991 obsolete transcription factor import into nucleus IEA
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0043313 regulation of neutrophil degranulation IEA
 biological_processGO:0043366 beta selection IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045401 positive regulation of interleukin-3 biosynthetic process IEA
 biological_processGO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation IEA
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IEA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050764 regulation of phagocytosis IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IMP
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071226 cellular response to molecule of fungal origin IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0090237 regulation of arachidonic acid secretion IEA
 biological_processGO:0090330 regulation of platelet aggregation IEA
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019815 B cell receptor complex IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032009 early phagosome IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042101 T cell receptor complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0004716 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0035325 Toll-like receptor binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Integrin alphaIIb beta3 signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000379 ITGB3 / P05106* / O54890* / AC068234.1* / Integrin beta-3 * / integrin subunit beta 3*  / complex / reaction
 ENSGALG00000001476 RAP1A / RAP1A, member of RAS oncogene family / P62834* / P62835* / RAS-related protein 1a*  / complex / reaction
 ENSGALG00000002548 TLN1 / talin-1 / P26039* / Q9Y490*  / complex / reaction
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000003578 FN1 / fibronectin 1 / P02751* / P11276* / Fibronectin Anastellin*  / complex / reaction
 ENSGALG00000007579 APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / complex / reaction
 ENSGALG00000009268 FGG / fibrinogen gamma chain / P02679* / Q8VCM7*  / complex / reaction
 ENSGALG00000009927 RAP1B / Q5ZHX1 / Ras-related protein Rap-1b / Q99JI6* / P61224* / RAS related protein 1b* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / complex
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / reaction
 ENSGALG00000003750 PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *  / complex / reaction
 ENSGALG00000004958 BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / complex / reaction
 ENSGALG00000023781 TREM2 / triggering receptor expressed on myeloid cells 2 / Q99NH8* / Q9NZC2*  / complex
 ENSGALG00000033507 PLCG2 / phospholipase C gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *  / complex / reaction
 ENSGALG00000035492 ELMO1 / engulfment and cell motility 1 / Q8BPU7* / Q92556* / Engulfment and cell motility protein 1 *  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction
 ENSGALG00000009262 FGB / fibrinogen beta chain / P02675* / Q8K0E8* / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain*  / complex / reaction






 

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